Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities
Tremulane sesquiterpenes from cultures of the fungus Phellinus igniarius and their vascular-relaxing activities
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DOI：
10.1016/j.phytol.2014.10.019
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发表时间：
2014-12
影响因子：
1.7
通讯作者：
Ronghua Yin;Zhen-Zhu Zhao;Heping Chen;Xia Yin;X. Ji;Zejun Dong;Zheng-Hui Li;Tao Feng;Jikai Liu
中科院分区：
文献类型：
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作者：
Ronghua Yin;Zhen-Zhu Zhao;Heping Chen;Xia Yin;X. Ji;Zejun Dong;Zheng-Hui Li;Tao Feng;Jikai Liu
本文报道了从真菌松菌（Funguslinusigniarius）的培养物中分离得到的5个新的银耳烷型倍半萜（1-5）和7个已知倍半萜（6-12），分别鉴定为6β，11，12-三羟基银耳烯（1），11，12-二羟基-7 β-过氧羟基银耳烯（2），6β，12-二羟基银耳烯（3），10β，12-二羟基银耳烯（3），12-二羟基-银耳烯（4）和12，15-二羟基-银耳烯（5）。评价化合物1 - 6的血管舒张活性。在体外实验中，在3 × 10− 4 M浓度下，它们对苯肾上腺素诱导的血管收缩表现出血管舒张活性，舒张率分别为29.9%、39.9%、48.5%、78.7%、32.3%和59.3%。化合物1、4和6对KCl引起的血管收缩有不同程度的舒张作用，舒张率分别为31.3%、57.7%和14.0%。
Five new tremulane sesquiterpenes (1–5), together with seven known ones (6–12), were isolated from cultures of the fungusPhellinus igniarius.The new compounds were established as 6β,11,12-trihydroxy-tremul-1(10)-ene (1), 11,12-dihydroxyl-7β-peroxy-hydroxyl-tremul-1(10)-ene (2), 6β,12-dihydroxy-tremulene (3), 10β,12-dihydroxy-tremulene (4), and 12,15-dihydroxy-tremulene (5) on the basis of their MS and NMR data. Compounds1–6were evaluated for their vascular-relaxing activities. In preliminaryin vitroassays, at 3 × 10−4M, they showed vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxing rates of 29.9%, 39.9%, 48.5%, 78.7%, 32.3%, and 59.3%, respectively. In addition, compounds1,4, and6exhibited different levels of vascular-relaxing activities against KCl-induced vasoconstriction with relaxing rates of 31.3%, 57.7%, and 14.0%, as compared with the blank control.