Effect of the somatostatin analogue octreotide acetate on hemostasis in humans.
Effect of the somatostatin analogue octreotide acetate on hemostasis in humans.
复制标题
生长抑素类似物醋酸奥曲肽对人体止血的影响。
DOI：
10.1016/s0025-6196(12)61010-6
复制
发表时间：
1991
影响因子：
8.9
通讯作者：
Bowie,EJ
中科院分区：
文献类型：
--
作者：
Witzig,TE;Kvols,LK;Moertel,CG;Bowie,EJ
醋酸奥曲肽是一种生长抑素类似物，已被证明可以改善良、恶性肿瘤激素过度分泌的副作用。这种药物抑制恶性细胞生长和控制胃肠道出血的能力将促使更多的临床试验。由于其中一些患者可能有血小板减少、血小板功能障碍或凝血功能障碍，我们研究了15名患者在服用奥曲肽前后14天的血小板功能和凝血功能测试，奥曲肽剂量为500μg，每天三次。我们发现这些测试的结果没有实质性的变化，也没有患者经历出血或血栓形成。这些结果表明，醋酸奥曲肽对人体的血小板功能或凝血系统没有不良影响。
Octreotide acetate is a somatostatin analogue that has been shown to ameliorate the side effects of excessive secretion of hormone from benign and malignant tumors. The ability of this drug to inhibit the growth of malignant cells and to control gastrointestinal hemorrhage will prompt additional clinical trials. Because some of these patients may have thrombocytopenia, platelet dysfunction, or a coagulopathy, we studied tests of platelet function and blood coagulation in 15 patients before and after 14 days of therapy with octreotide acetate at a dosage of 500 μg three times daily. We found no substantial change in the results of these tests, and no patient experienced bleeding or thrombosis. These results suggest that octreotide acetate does not adversely affect platelet function or the coagulation system in humans.