THE EFFECT OF RADIATION ON THE FRACTURE REPAIR PROCESS - A BIOMECHANICAL EVALUATION OF A CLOSED FRACTURE IN A RAT MODEL
THE EFFECT OF RADIATION ON THE FRACTURE REPAIR PROCESS - A BIOMECHANICAL EVALUATION OF A CLOSED FRACTURE IN A RAT MODEL
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DOI：
10.1002/jor.1100070204
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发表时间：
1989-03-01
影响因子：
2.8
通讯作者：
PANJABI, MM
中科院分区：
文献类型：
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作者：
MARKBREITER, LA;PELKER, RR;PANJABI, MM
在大鼠模型上研究了单剂量照射对骨折愈合过程中生物力学参数的影响。在产生闭合性股骨中段骨折之前进行髓内钉固定。实验组暴露于900拉德骨折后3天，并与对照组进行了比较，类似的骨折，没有收到辐射。在手术后2-16周的时间间隔内处死动物，并测试骨直至扭转失败。在辐照组中，观察到与骨折愈合相关的生物力学参数（失效扭矩、扭转刚度、失效角度和生物力学阶段）延迟4周。尽管这种延迟在正常的时间进展，分期和刚度接近正常对照组在8周内。然而，在本研究结束时，失效扭矩仍低于正常水平。这些结果不同于先前使用开放性骨折模型的研究。
The effects of a single dose of irradiation on the biomechanical parameters of the fracture healing process were studied in a rat model. Intramedullary pinning was performed before production of a closed femoral midshaft fracture. The experimental group was exposed to 900 rad 3 days after fracture and was compared with a control group with a similar fracture that received no irradiation. Animals were killed at intervals ranging from 2-16 weeks after surgery and the bones were tested until failure in torsion. In the irradiated groups, a delay of 4 weeks was noted in the biomechanical parameters associated with fracture healing (torque to failure, torsional stiffness, angle to failure, and biomechanical stage). Despite this delay in the normal temporal progression, the staging and stiffness approached normal controls within an 8-week period. However, the torque to failure remained below normal levels at the conclusion of this study. These results differ from a previous study using an open fracture model.