Longitudinal study of quality of life in people with advanced Alzheimer's disease
Longitudinal study of quality of life in people with advanced Alzheimer's disease
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DOI：
10.1176/appi.ajgp.9.2.160
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发表时间：
2001-03-01
影响因子：
7.2
通讯作者：
Stern, Y
中科院分区：
文献类型：
--
作者：
Albert, SM;Jacobs, DM;Stern, Y
作者检查了晚期阿尔茨海默病患者（[AD]; N = 150）健康相关生活质量的三个指标：限制在家，无效活动和无效积极影响，患者代理人报告的ns。在控制了社会人口学指标、疗养院状况和随访期间死亡的模型中，痴呆严重程度、所有三个疾病里程碑的预测发病时间。在随访期间痴呆恶化的患者更有可能达到每个里程碑。这些结果代表了患者护理的关键里程碑;它们对疾病进展敏感，并且它们可能对研究晚期AD的治疗有用。
The authors examined three indicators of health-related quality of life in people with advanced Alzheimer's disease ([AD]; N = 150): confinement to home, null activity, and null positive affect, ns reported by patient proxies. Dementia severity, predicted time-to-onset for all three disease milestones in models that controlled for sociodemographic indicators, nursing home status, and death in the follow-up period Patients whose dementia worsened over follow-up were more likely, to reach each milestone. These outcomes represent key milestones in the care of patients; they are sensitive to disease progression, and they are likely to be useful for studying treatment in advanced AD.