Tomato juice supplementation in young women reduces inflammatory adipokine levels independently of body fat reduction
Tomato juice supplementation in young women reduces inflammatory adipokine levels independently of body fat reduction
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DOI：
10.1016/j.nut.2014.11.008
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发表时间：
2015-05-01
期刊：
影响因子：
4.4
通讯作者：
Chao, Pei-Min
中科院分区：
文献类型：
--
作者：
Li, Yu-Fen;Chang, Ya-Yuan;Chao, Pei-Min
目的：番茄红素是一种胡萝卜素和植物化学物质，已知可预防代谢性疾病。它存在于红色水果和蔬菜中，主要是西红柿。本研究旨在显示番茄汁对一般健康人群中与代谢健康和脂肪因子谱相关的指数的补充效果。方法：共招募了30名体重指数（BMI）>= 20的年轻女性（20- 30岁），其中25人完成了整个研究。受试者继续正常饮食和运动计划，但每天给予280 mL番茄汁（含有32.5 mg番茄红素），持续2个月。代谢指标，包括人体测量数据和血糖，血脂，脂肪因子，番茄红素和抗氧化剂的血清水平，进行了比较干预前后。番茄汁补充剂显著降低了体重、体脂、腰围、BMI以及胆固醇、单核细胞趋化蛋白-1（MCP-1）和硫代巴比妥反应物质的血清水平，同时显著增加了脂联素、甘油三酯和番茄红素。当受试者按体脂变化分层时，即，减少或不减少（包括增加或无变化），番茄汁诱导的腰围、血清胆固醇和MCP-1水平的减少以及脂联素和番茄红素水平的增加在两个亚组中均可见。腰围，胆固醇，MCP-1，脂联素水平的变化仍然显着调整后，每个协变量单独，与番茄红素的例外。结论：这些结果表明，每天补充番茄汁降低腰围，以及血清胆固醇和炎症性脂肪因子水平的年轻健康女性，这些影响是无关的体脂变化。(C)2015 Elsevier Inc. All rights reserved.
Objectives: Lycopene is a carotene and phytochemical known to protect against metabolic diseases. It is found in red fruits and vegetables, predominantly tomatoes. This study aimed to show the supplementation effect of tomato juice on indices associated with metabolic health and adipokine profiles in generally healthy people.Methods: A total of 30 young females (20- to 30-years-old) with a body mass index (BMI) >= 20 were recruited, of whom 25 completed the entire study. The subjects continued with their normal diet and exercise schedule, but were given 280 mL of tomato juice (containing 32.5 mg of lycopene) daily for 2 mo. Metabolic indices, including anthropometric data and serum levels of glucose, lipids, adipokines, lycopene, and antioxidants, were compared pre- and postintervention.Results: Tomato juice supplementation significantly reduced body weight, body fat, waist circumference, BMI, and serum levels of cholesterol, monocyte chemoattractant protein-1 (MCP-1), and thiobarbituric reactive substances, while significantly increasing serum levels of adiponectin, triglyceride, and lycopene. When subjects were stratified by body fat change, i.e., reduction or non-reduction (including increase or no change), the tomato juice-induced reduction in waist circumference, serum cholesterol, and MCP-1 levels and increase in adiponectin and lycopene levels were seen in both subgroups. The changes in waist circumference, cholesterol, MCP-1, and adiponectin levels remained significant after adjusting for each covariable individually, with the exception of lycopene.Conclusions: These results show that daily tomato juice supplementation reduces waist circumference, as well as serum cholesterol and inflammatory adipokine levels in young healthy women and that these effects are unrelated to body fat changes. (C) 2015 Elsevier Inc. All rights reserved.