Impact of Intestinal Microbiota on Reconstitution of Circulating Monocyte, Dendritic Cell, and Natural Killer Cell Subsets in Adults Undergoing Single-Unit Cord Blood Transplantation.
Impact of Intestinal Microbiota on Reconstitution of Circulating Monocyte, Dendritic Cell, and Natural Killer Cell Subsets in Adults Undergoing Single-Unit Cord Blood Transplantation.
复制标题
肠道微生物群对接受单单位脐带血移植的成人循环单核细胞、树突状细胞和自然杀伤细胞亚群重建的影响。
DOI：
10.1016/j.bbmt.2020.08.009
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Tojo A.
中科院分区：
文献类型：
--
作者：
Konuma T;Kohara C;Watanabe E;Takahashi S;Ozawa G;Inomata K;Suzuki K;Mizukami M;Nagai E;Okabe M;Isobe M;Kato S;Oiwa-Monna M;Takahashi S;Tojo A.
肠道微生物群在宿主先天免疫细胞（如单核细胞、树突状细胞（dc）和自然杀伤细胞（NK））的发育中起着重要作用。我们研究了38例接受单单位脐带血移植（CBT）的成年患者肠道微生物群与循环单核细胞、DC细胞和NK细胞亚群随后的免疫重建之间的关系。根据Chao1指数测量，1个月时肠道微生物群多样性较高与CBT后7个月时浆细胞样dc计数较高显著相关。未加权UniFrac距离的主坐标分析显示，在cbt后7个月，较高和较低的经典单核细胞重构之间存在显著差异。在cbt后7个月，奈瑟菌科、伯克霍尔德菌科、丙酸杆菌科和科里杆菌科在较高的经典单核细胞重建中增加，而拟杆菌科在cbt后7个月在较低的经典单核细胞重建中增加。这些数据表明，肠道菌群组成影响单单位CBT后经典单核细胞和浆细胞样dc的免疫重建。
The intestinal microbiota plays a fundamental role in the development of host innate immune cells, such as monocytes, dendritic cells (DCs), and natural killer (NK) cells. We examined the association between intestinal microbiota and subsequent immune reconstitution of circulating monocyte, DC, and NK cell subsets in 38 adult patients undergoing single-unit cord blood transplantation (CBT). A higher diversity of intestinal microbiota at 1 month was significantly associated with higher counts of plasmacytoid DCs at 7 months after CBT, as measured by the Chao1 index. Principal coordinate analysis of unweighted UniFrac distances showed significant differences between higher and lower classical monocyte reconstitution at 7 months post-CBT. The familiesNeisseriaceae, Burkholderiaceae, Propionibacteriaceae, andCoriobacteriaceaewere increased in higher classical monocyte reconstitution at 7 months post-CBT, whereas the familyBacteroidaceaewas increased in lower classical monocyte reconstitution at 7 months post-CBT. These data show that intestinal microbiota composition affects immune reconstitution of classical monocyte and plasmacytoid DCs following single-unit CBT.