Cortical reorganization during PASAT task in MS patients with preserved working memory functions
Cortical reorganization during PASAT task in MS patients with preserved working memory functions
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DOI：
10.1016/j.neuroimage.2005.12.030
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发表时间：
2006-06-01
期刊：
影响因子：
5.7
通讯作者：
Avila, C.
中科院分区：
文献类型：
--
作者：
Forn, C.;Barros-Loscertales, A.;Avila, C.
多发性硬化症 (MS) 中的皮质重组被定义为一种补偿机制，要求 MS 患者过度激活特定的大脑区域，以便执行对照任务。为了通过节奏听觉连续相加测试 (PASAT) 任务研究这一过程，我们选择了 15 名在正常范围内执行 PASAT 任务的多发性硬化症患者和 10 名健康对照。一旦选定，我们就使用功能磁共振成像 (fMRI) 来研究两组参与 PASAT 表现的大脑区域。结果显示，该任务激活了两组的左额叶皮层（BA6和9）和顶叶皮层（BA7和40），但与对照组相比，多发性硬化症患者的左前额叶皮层（BA9、44和45）表现出更强的激活。这些结果证实了 Audoin 等人事后获得的结果。 [Audoin, B., Ibarrola, D., Ranjeva, J.P., Confort-Gouny, S., Malikova, I., Ali-Cherif, A.M., Pelletier, J., Cozzone, P., et al., 2003。在 MS 最早阶段的认知任务期间通过 fMRI 观察到的补偿性皮质激活。哼。大脑地图。 20, 51-581，我们将其解释为显示真正的皮质重组。 (c) 2005 Elsevier Inc. 保留所有权利。
Cortical reorganization in multiple sclerosis (MS) is defined as a compensatory mechanism which requires MS patients to overactivate specific brain areas in order to perform the task as controls. To investigate this process with the Paced Auditory Serial Addition Test (PASAT) task, we selected 15 MS patients who performed the PASAT task within-normal limits and 10 healthy controls. Once selected, we used functional magnetic resonance imaging (fMRI) to investigate brain areas involved in PASAT performance in both groups. Results showed that the task activated the left frontal (BA6 and 9) and parietal cortex (BA7 and 40) in both groups, but MS patients showed a stronger activation in the left prefrontal cortex (BA9, 44 and 45) when compared with controls. These results confirmed those obtained post hoc by Audoin et al. [Audoin, B., Ibarrola, D., Ranjeva, J.P., Confort-Gouny, S., Malikova, I., Ali-Cherif, A.M., Pelletier, J., Cozzone, P., et al., 2003. Compensatory cortical activation observed by fMRI during cognitive task at the earliest stage of MS. Hum. Brain Mapp. 20, 51-581, and we interpreted this as showing true cortical reorganization. (c) 2005 Elsevier Inc. All rights reserved.