Dependence in Alzheimer's disease and service use costs, quality of life, and caregiver burden: The DADE study
Dependence in Alzheimer's disease and service use costs, quality of life, and caregiver burden: The DADE study
复制标题
DOI：
10.1016/j.jalz.2014.03.001
复制
发表时间：
2015-03-01
影响因子：
14
通讯作者：
Lacey, Loretto
中科院分区：
文献类型：
--
作者：
Jones, Roy W.;Romeo, Renee;Lacey, Loretto
背景：大多数确定患者和照顾者的特征和成本如何随阿尔茨海默病(AD)进展而变化的模型都集中在一个方面，例如认知。AD不是由单个领域定义的；通过关注单个方面来跟踪进展可能意味着其他重要方面没有得到足够的解决。依赖性被认为是疾病进展的一个更好的标志。方法：这是一项横断面观察性研究(18个英国站点)。249名社区或住院患者，可能/可能患有AD，简易精神状态检查(3-26)，以及一名知识丰富的告密者参与。结果：依赖性(依赖量表[DS])与临床严重程度测量(认知、功能和行为)之间存在显著关联。双变量和多变量模型显示DS与服务使用成本、患者生活质量和照顾者感知的负担之间存在显著关联。结论：依赖的结构可能有助于将认知、功能和行为变化的综合影响转化为更容易解释的形式。DS在临床试验/研究中对AD患者的评估是有用的。(C)2015年阿尔茨海默氏症协会。爱思唯尔公司出版，版权所有。
Background: Most models determining how patient and caregiver characteristics and costs change with Alzheimer's disease (AD) progression focus on one aspect, for example, cognition. AD is inadequately defined by a single domain; tracking progression by focusing on a single aspect may mean other important aspects are insufficiently addressed. Dependence has been proposed as a better marker for following disease progression.Methods: This was a cross-sectional observational study (18 UK sites). Two hundred forty-nine community or institutionalized patients, with possible/probable AD, Mini-Mental State Examination (3-26), and a knowledgeable informant participated.Results: Significant associations noted between dependence (Dependence Scale [DS]) and clinical measures of severity (cognition, function, and behavior). Bivariate and multivariate models demonstrated significant associations between DS and service use cost, patient quality of life, and caregiver perceived burden.Conclusion: The construct of dependence may help to translate the combined impact of changes in cognition, function, and behavior into a more readily interpretable form. The DS is useful for assessing patients with AD in clinical trials/research. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.