Evolutionary dynamics of invasion and escape
Evolutionary dynamics of invasion and escape
复制标题
DOI：
10.1016/j.jtbi.2003.08.014
复制
发表时间：
2004-01-21
影响因子：
2
通讯作者：
Nowak, MA
中科院分区：
文献类型：
--
作者：
Iwasa, Y;Michor, F;Nowak, MA
每当生命想要入侵新的栖息地或逃离致命的选择压力时，一些突变可能是产生可持续复制所必需的。我们可以想象这样的情况：（i）寄生虫感染了一个新的宿主;（ii）一个物种试图入侵一个新的生态位;（iii）癌细胞逃避化疗;（iv）病毒或微生物逃避抗微生物治疗;（v）在生命之初，组合化学反复尝试产生自我复制的分子。所有这些看似无关的情况在达尔文动力学方面都有一个共同的结构：一个基本繁殖比小于1的复制因子试图找到一些允许无限生存的突变。我们开发了一个通用的理论，基于多类型的分支过程，来描述入侵和逃逸的进化动力学。(C)2003 Elsevier Ltd.保留所有权利。
Whenever life wants to invade a new habitat or escape from a lethal selection pressure, some mutations may be necessary to yield sustainable replication. We imagine situations like (i) a parasite infecting a new host, (ii) a species trying to invade a new ecological niche, (iii) cancer cells escaping from chemotherapy, (iv) viruses or microbes evading anti-microbial therapy, and also (v) the repeated attempts of combinatorial chemistry in the very beginning of life to produce self-replicating molecules. All such seemingly unrelated situations have a common structure in terms of Darwinian dynamics: a replicator with a basic reproductive ratio less than one attempts to find some mutations that allow indefinite survival. We develop a general theory, based on multitype branching processes, to describe the evolutionary dynamics of invasion and escape. (C) 2003 Elsevier Ltd. All rights reserved.