HEROIN AND COCAINE INTRAVENOUS SELF-ADMINISTRATION IN RATS - MEDIATION BY SEPARATE NEURAL SYSTEMS
HEROIN AND COCAINE INTRAVENOUS SELF-ADMINISTRATION IN RATS - MEDIATION BY SEPARATE NEURAL SYSTEMS
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DOI：
10.1007/bf00428151
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发表时间：
1982-01-01
影响因子：
3.4
通讯作者：
KOOB, GF
中科院分区：
文献类型：
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作者：
ETTENBERG, A;PETTIT, HO;KOOB, GF
单独的神经系统介导阿片类药物和精神运动兴奋剂的增强特性的假设在训练有素静脉注射杠杆按压的大鼠中进行了测试。每天 3 小时注射可卡因或海洛因。阿片受体拮抗剂药物纳曲酮的预处理使海洛因自我给药量呈剂量依赖性增加，但对可卡因自我给药的速率或模式没有影响。用低剂量的多巴胺拮抗剂药物α-氟哌噻吨进行预处理产生可卡因的剂量依赖性增加，但不导致海洛因自我施用。高剂量的α-氟哌噻吨消除了对可卡因的所有反应并略微减少了苍鹭的自我给药。两种拮抗剂药物发挥其行为效应的特异性强烈表明，独立的神经底物负责海洛因和可卡因的增强作用。
The hypothesis that separate neural systems mediate the reinforcing properties of opiate and psychomotor stimulant drugs was tested in rats trained to lever-press for i.v. injections of either cocaine or heroin during daily 3-h sessions. Pretreatment with the opiate receptor antagonist drug naltrexone produced dose-dependent increases in heroin self-administration but had no effect on the rate or pattern of cocaine self-administration. Pretreatment with low doses of the dopamine antagonist drug .alpha.-flupenthixol produced dose-dependent increases in cocaine but not heroin self-administration. High doses of .alpha.-flupenthixol eliminated all responding for cocaine and slightly reduced heron self-administration. The specificity with which the 2 antagonist drugs exerted their behavioral effects strongly suggests that independent neural substrates are responsible for the reinforcing actions of heroin and cocaine.