Brain volume decline in aging
Brain volume decline in aging
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DOI：
10.1001/archneurol.2007.27
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Buckner, Randy L.
中科院分区：
文献类型：
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作者：
Fotenos, Anthony F.;Mintun, Mark A.;Buckner, Randy L.
目的：评估社会经济地位（SES）和非痴呆老年人脑结构变化之间的关系，并确定临床前阿尔茨海默病（AD）的潜在作用。设计：横断面和纵向观察。设置：阿尔茨海默病研究中心，圣刘易斯，密苏里州。参与者：志愿者样本362非痴呆成年人，年龄18至93岁。对100名主要队列的痴呆和SES进行了评估;临床痴呆评分（CDR）为0（无痴呆）和中等、高中或高SES是合格的要求。所有362例患者均接受了磁共振成像;在主要的100例患者中，91例接受了随访临床评估，33例接受了至少3年的随访磁共振成像。一个单独的样本58 CDR 0参与者（年龄47至86岁）参加了淀粉样蛋白成像与匹兹堡化合物B（Pi B）标记的放射性碳（C-11）。主要结果测量：全脑体积调整头部大小（aWBV）和每年的变化。结果：aWBV下降0：22%，每年之间的年龄20和80岁的加速下降，在先进的老龄化。在CDR为0的老年人（> 65岁）中，控制年龄和性别的影响，较高的SES与较小的aWBV相关（从中等特权到高特权的样本范围差异为3.8%，P
Objectives: To assess the relation between socioeconomic status (SES) and structural brain change in nondemented older adults and to ascertain the potential role of preclinical Alzheimer disease (AD).Design: Cross-sectional and longitudinal observation.Setting: Alzheimer's Disease Research Center, St Louis, Missouri.Participants: Volunteer sample of 362 nondemented adults aged 18 to 93 years. The main cohort of 100 was evaluated for dementia and SES; a Clinical Dementia Rating (CDR) of 0 (no dementia) and middle, high-middle, or high SES was required for eligibility. All 362 received magnetic resonance imaging; of the main 100, 91 received follow-up clinical assessment, and 33 received follow-up magnetic resonance imaging over at least a 3-year interval. A separate sample of 58 CDR 0 participants (aged 47 to 86 years) took part in amyloid imaging with Pittsburgh Compound B (PiB) labeled with radioactive carbon (C-11).Main Outcome Measures: Whole-brain volume adjusted for head size (aWBV) and change per year.Results: aWBV declined by 0:22% per year between the ages of 20 and 80 years with accelerated decline in advanced aging. Controlling for effects of age and sex in older adults (> 65 years) with CDR 0, higher SES was associated with smaller aWBV (3.8% difference spanning the sample range from middle to high privilege, P