Layer-specific expression of Cl− transporters and differential [Cl−]i in newborn rat cortex
Layer-specific expression of Cl− transporters and differential [Cl−]i in newborn rat cortex
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新生大鼠皮质中 Cl− 转运蛋白的层特异性表达和差异 [Cl−]i
DOI：
10.1097/00001756-200212200-00012
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发表时间：
2002
期刊：
影响因子：
1.7
通讯作者：
A. Fukuda
中科院分区：
文献类型：
--
作者：
C. Shimizu;Masamichi Yokokura;A. Okabe;Masahiko Ikeda;Kohji Sato;W. Kilb;H. Luhmann;A. Fukuda
GABA是成年人大脑中主要的抑制性神经递质。然而，GABA能传递在出生后早期发育过程中是去极化的，这表明调节神经元Cl−稳态的阳离子-Cl −共转运蛋白表达的变化是GABA能功能个体发生的基础。新皮层中Cl-协同转运蛋白mRNA表达的发育变化方向相反，NKCC 1（Cl-摄取）和KCC 2（Cl-排出）。新生儿NKCC 1 mRNA表达在脑室区最高，其次是皮质板，然后是V/VI层，而KCC 2 mRNA表达则相反。[Cl−]i水平与NKCC 1 mRNA的等级顺序相同。因此，新皮层神经元中Cl−稳态的个体发生可以通过NKCC 1和KCC 2的差异表达来调节。
GABA is the main inhibitory neurotransmitter in the adult brain. However, GABAergic transmission is depolarizing during early postnatal development, suggesting that changes in the expression of cation–Cl− co-transporters regulating neuronal Cl− homeostasis underlie the ontogeny of GABAergic functions. The developmental changes in the expressions of Cl− co-transporter mRNAs in the neocortex were in opposite directions for NKCC1 (Cl− uptake) and KCC2 (Cl− extrusion). In the newborn, NKCC1 mRNA expression was highest in ventricular zone followed by cortical plate, and then by Layer V/VI, while the reverse was true for KCC2 mRNA. The [Cl−]i levels were in the same rank order as for NKCC1 mRNA. Thus, the ontogeny of Cl− homeostasis in neocortical neurons could be regulated via the differential expression of NKCC1 and KCC2.
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影响因子：
2.5
作者：
LUHMANN, HJ;PRINCE, DA
通讯作者：
PRINCE, DA
DOI：
10.1016/s0165-3806(98)00078-9
发表时间：
1998-08-08
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Clayton, GH;Owens, GC;Smith, RL
通讯作者：
Smith, RL
影响因子：
2.9
作者：
BIWERSI, J;VERKMAN, AS
通讯作者：
VERKMAN, AS
DOI：
10.1002/(sici)1097-4695(19990615)39:4
发表时间：
1999-06-15
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Lu, J;Karadsheh, M;Delpire, E
通讯作者：
Delpire, E