Liver stem cells and hepatocellular carcinoma.
Liver stem cells and hepatocellular carcinoma.
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DOI：
10.1002/hep.22704
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发表时间：
2009-01
期刊：
影响因子：
13.5
通讯作者：
Reddy, E. P.
中科院分区：
文献类型：
--
作者：
Mishra, Lopa;Banker, Tanuj;Murray, Joseph;Byers, Stephen;Thenappan, Arun;He, Aiwu Ruth;Shetty, Kirti;Johnson, Lynt;Reddy, E. P.
虽然癌症干细胞（CSC）的存在是在40多年前首次提出的，但仅在过去十年中，这些细胞才在血液恶性肿瘤中被发现，最近在包括肝脏，乳腺，前列腺，脑和结肠的实体瘤中被发现。干细胞的不断增殖是肝组织中的重要组成部分。在这些更新的组织中，突变很可能会导致改变的干细胞的扩增，使额外的突变和肿瘤进展的机会永久存在并增加。然而，对于早期检测重要的肝细胞癌干细胞的许多细节仍然知之甚少，包括起源的精确细胞，分子遗传学以及负责肝细胞癌（HCC）高度侵袭性临床表现的机制。探索CSC与正常干细胞之间的差异不仅对于理解肿瘤生物学至关重要，而且对于开发有效靶向患者这些细胞的特异性疗法也至关重要。这些想法引起了人们对通过转化生长因子β（TGF-β）、Notch、Wnt和Hedgehog途径控制干细胞增殖的关注。最近的证据还表明TGF-β信号传导途径在肝细胞癌抑制和内胚层形成中的关键作用，表明该途径在肿瘤抑制以及从干细胞或祖细胞阶段分化的进展中的双重作用。这篇综述为检测和分析肿瘤干细胞作为治疗癌症（如HCC）的最有效方法之一提供了理论基础。
Although the existence of cancer stem cells (CSCs) was first proposed over 40 years ago, only in the past decade have these cells been identified in hematological malignancies, and more recently in solid tumors that include liver, breast, prostate, brain, and colon. Constant proliferation of stem cells is a vital component in liver tissues. In these renewing tissues, mutations will most likely result in expansion of the altered stem cells, perpetuating and increasing the chances of additional mutations and tumor progression. However, many details about hepatocellular cancer stem cells that are important for early detection remain poorly understood, including the precise cell(s) of origin, molecular genetics, and the mechanisms responsible for the highly aggressive clinical picture of hepatocellular carcinoma (HCC). Exploration of the difference between CSCs from normal stem cells is crucial not only for the understanding of tumor biology but also for the development of specific therapies that effectively target these cells in patients. These ideas have drawn attention to control of stem cell proliferation by the transforming growth factor beta (TGF-β), Notch, Wnt, and Hedgehog pathways. Recent evidence also suggests a key role for the TGF-β signaling pathway in both hepatocellular cancer suppression and endoderm formation, suggesting a dual role for this pathway in tumor suppression as well as progression of differentiation from a stem or progenitor stage. This review provides a rationale for detecting and analyzing tumor stem cells as one of the most effective ways to treat cancers such as HCC.
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DOI：
10.1186/bcr920
发表时间：
2004
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Dontu G;Jackson KW;McNicholas E;Kawamura MJ;Abdallah WM;Wicha MS
通讯作者：
Wicha MS
影响因子：
10.5
作者：
Dontu, G;Abdallah, WM;Wicha, MS
通讯作者：
Wicha, MS
影响因子：
29.4
作者：
Crosby, HA;Kelly, DA;Strain, AJ
通讯作者：
Strain, AJ
影响因子：
11.4
作者：
Cook, D;Fry, MJ;Dale, TC
通讯作者：
Dale, TC
影响因子：
5.3
作者：
Einstein, M;Monga, SPS;Deng, CX
通讯作者：
Deng, CX