Estimation of Iodine Intake from Various Urinary Iodine Measurements in Population Studies
Estimation of Iodine Intake from Various Urinary Iodine Measurements in Population Studies
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DOI：
10.1089/thy.2009.0094
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发表时间：
2009-11-01
期刊：
影响因子：
6.6
通讯作者：
Jorgensen, Torben
中科院分区：
文献类型：
--
作者：
Vejbjerg, Pernille;Knudsen, Nils;Jorgensen, Torben
背景资料：碘摄入量通常通过替代测量来测量，即尿碘排泄，因为几乎所有摄入的碘都通过尿液排泄。然而，尿液采集和结果报告的方法各不相同。这些方法，以及它们的优点和缺点，在这篇文章中被认为是。总结：有两种主要的方法，其中尿液可以收集碘测量。第一种是在一段时间内收集尿液，通常是24小时。第二种方法是采集尿液样本。尿碘值可以表示为含量或浓度，并在不进行修改的情况下报告或作为同一样本中肌酐的函数报告。用于碘测量的24小时尿通常被认为是精确估计个体碘排泄量和碘摄入量的“参考标准”。由于24小时采集很难对大量人群进行，因此在人群研究中，单点尿液样本优于24小时尿液采集。尿中的碘浓度取决于碘和液体的摄入量。这一点，以及每日碘摄入量存在相当大的变化这一事实，使得现场尿液样本中的碘测量对于评估个体的碘缺乏不可靠，尽管它们可以用于筛查来自胺碘酮和某些放射造影剂等来源的大量碘暴露。在至少有500名受试者的人群中，点尿碘浓度的中位数是衡量人群碘摄入量的可靠指标，因为碘摄入量和尿量的日常变化趋于平稳。将尿碘浓度表示为尿肌酸酐的函数可用于校正液体摄入的影响。当这样做时，建议调整特定年龄和性别的肌酐排泄在给定population.Conclusion：在碘摄入量的研究中，正确选择的方法收集尿和尿碘测量的结果表示格式是必不可少的，以避免误解的数据上的碘状态的人口或个人。
Background: Iodine intake is often measured by a surrogate measure, namely urine iodine excretion as almost all ingested iodine is excreted in the urine. However, the methods for urine collection and the reporting of the results vary. These methods, and their advantages and disadvantages, are considered in this article.Summary: There are two main ways in which urine can be collected for iodine measurement. The first is the collection of urine over a period, usually 24 hours. The second is the collection of a spot urinary sample. Urinary iodine values can be expressed as the content or concentration and reported without modification or as a function of creatinine in the same sample. The 24-hour urine for iodine measurement is often considered as the ``reference standard'' for giving a precise estimate of the individual iodine excretion and thereby iodine intake. As 24-hour collections are difficult to perform for large number of persons, single spot urinary samples are preferable to the 24-hour urinary collections in population studies. The iodine concentration in urine depends on the intake of both iodine and fluid. This, and the fact that there is a considerable variability in the daily iodine intake, makes the iodine measurement in spot urine samples unreliable for evaluating individuals for iodine deficiency, though they can be used to screen for exposure to large amounts of iodine from sources such as amiodarone and certain radiographic contrast agents. In populations of at least 500 subjects, the median value of spot urinary iodine concentration is a reliable measure of the iodine intake in the population as there is a leveling out of the day-to-day variation in iodine intake and urinary volume. Expressing the urinary iodide concentration as a function of urinary creatinine is useful in correcting for the influence of fluid intake. When doing so, it is recommended to adjust for the age- and sex-specific creatinine excretion in the given population.Conclusion: In studies of iodine intake, the correct choice of the method for collecting urine and the format for expressing the results of urine iodine measurement is essential to avoid misinterpretation of data on the iodine status of a population or individuals.