Effects of specific activation of mu-, delta- and kappa-opioid receptors on the secretion of luteinizing hormone and prolactin in the ovariectomized rat.
Effects of specific activation of mu-, delta- and kappa-opioid receptors on the secretion of luteinizing hormone and prolactin in the ovariectomized rat.
复制标题
mu-、delta-和 kappa-阿片受体的特异性激活对卵巢切除大鼠黄体生成素和催乳素分泌的影响。
DOI：
10.1159/000124712
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发表时间：
1987
影响因子：
4.1
通讯作者：
Yagenova,SV
中科院分区：
文献类型：
--
作者：
Leadem,CA;Yagenova,SV
随着μ， δ和kopioid受体的高特异性配体的发展，确定每种受体类型的激活对LH和催乳素（PRL）分泌的影响是很有意义的。将化合物以不同浓度（10 μ l/h）注入未麻醉的去卵巢大鼠第三脑室。1µg/h和10µg/h的激动剂DAGO均能显著抑制LH分泌，显著刺激PRL释放。δ激动剂DPDPE在1µg/h时对两种激素均无影响，但在10µg/h时抑制LH分泌。高剂量DPDPE对PRL释放仍无影响。kagonist u50,488在10µg/h时对两种激素均无影响，但在100µg/h时，可显著抑制LH释放，并显著增加PRL。100µg/h的纳洛酮与高剂量的每一种激动剂的联合输注完全阻断了两种激素对每一种激动剂的反应，但有一个例外：U50,488H对PRL的高度可变刺激不受影响，从而表明U50,488H对PRL分泌的非特异性作用。这些结果表明：(1)激活µ受体可抑制LH分泌，刺激PRL释放；(2)激活δ受体会抑制LH的分泌，但对PRL的释放没有影响；(3)激活k受体会抑制LH的释放，但对PRL的分泌有不同程度的刺激。
With the recent development of highly specific ligands for the µ, δ andKopioid receptors it was of interest to define the effects of activation of each of these receptor types on LH and prolactin (PRL) secretion. The compounds were infused (10 µl/h) at various concentrations into the third cerebroventricle of unanesthetized, ovariectomized rats. The µ agonist, DAGO, at both 1 and 10 µg/h caused a significant suppression of LH secretion and a significant stimulation of PRL release. DPDPE, the δ agonist, had no effect on either hormone at 1 µg/h but inhibited LH secretion at 10 µg/h. There was still no effect of this high dose of DPDPE on PRL release. TheKagonist, U50,488H, had no effect on either hormone at 10 µg/h, but at 100 µg/h produced a significant suppression of LH release and a highly variable increase in PRL. Coinfusion of 100 µg/h of naloxone with the high dose of each of the agonists completely blocked the responses of both hormones to each of the agonists with one exception: the highly variable stimulation of PRL by U50,488H was not affected, thus indicating a nonspecific effect of U50,488H on PRL secretion. These results demonstrate that: (1) activation of the µ receptors produces an inhibition of LH secretion and a stimulation of PRL release; (2) activation of the δ receptors produces an inhibition of LH secretion but has no effect on PRL release, and (3) activation of theKreceptors produces an inhibition of LH release and a variable stimulation of PRL secretion.