Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.

Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.
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冠醚可减弱阿尔茨海默病的β淀粉样蛋白的聚集。

DOI：
10.1039/c4cc06029f
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发表时间：
2014
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
通讯作者：
Ran,Chongzhao
Ran,Chongzhao
中科院分区：
--
文献类型：
--
作者：
Tian,Yanli;Zhang,Xueli;Li,Yuyan;Shoup,TimothyM;Teng,Xin;Elmaleh,DavidR;Moore,Anna;Ran,Chongzhao

文献摘要

相似文献

在本报告中，我们推断冠醚对淀粉样蛋白β（Aβ）的非共价修饰可以抑制其聚集。我们证明了PiB和冠醚的缀合物PiB-C可以显着降低体外聚集。此外，双光子成像显示PiB-C可以有效地标记AD小鼠中的Aβ斑块和CAA。
In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.