NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF
NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF
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DOI：
10.1016/j.jchf.2018.10.014
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发表时间：
2019-02-01
影响因子：
13
通讯作者：
Felker, G. Michael
中科院分区：
文献类型：
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作者：
Daubert, Melissa A.;Adams, Kirkwood;Felker, G. Michael
本研究旨在评估生物标志物引导治疗与左心室（LV）重塑之间的关系。背景在射血分数降低（HFrEF）的心力衰竭患者中，尚不清楚降低利钠肽是否反映了心脏的结构和功能变化。本研究旨在评估生物标志物引导治疗与左室重构之间的关系。方法GUIDE-IT（使用生物标志物强化治疗心力衰竭的指导循证治疗）超声子研究是一项多中心研究，随机选择268例HFrEF（EF）患者，
OBJECTIVES This study aims to assess the association between biomarker-guided therapy and left ventricular (LV) remodeling.BACKGROUND In patients with heart failure with reduced ejection fraction (HFrEF), it is unclear if lowering natriuretic peptides reflects structural and functional changes in the heart. This study aims to assess the association between biomarker-guided therapy and left ventricular (LV) remodeling.METHODS The GUIDE-IT (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) Echo Substudy was a multicenter study that randomized 268 patients with HFrEF (EF