Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis.
Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis.
复制标题
LGR5（一种肠道干细胞标记物）在结直肠肿瘤发生的各个阶段的表达。
作者：
Kayoko Takeda;I. Kinoshita;Y. Shimizu;Y. Matsuno;T. Shichinohe;H. Dosaka
背景
BACKGROUND
The Wnt target LGR5 has been recently identified as a murine intestinal stem cell marker. Its role during each stage of human colorectal tumorigenesis remains to be determined.
PATIENTS AND METHODS
LGR5 expression was investigated by immunohistochemical analysis in 17 low-grade and 13 high-grade intraepithelial neoplasias and 30 adenocarcinomas.
RESULTS
The number of LGR5-positive cells increased tumor, with clustering of the cells to form patches. An apparent difference in their distribution among the tumorigenesis stages was observed. LGR5 expression in luminal surface showed a negative association with the progressive grade of tumors, while that in lower crypt exhibited a positive association with grade. In adenocarcinomas, LGR5 expression in luminal surface was negatively associated with pStage, while it was almost invariably high in lower crypt during advanced pStage disease.
CONCLUSION
These results suggest that the shifts in the distribution of LGR5-positive cells towards the lower crypt play a role in the development and progression of colorectal cancer.
影响因子：
--
作者：
S. Hsu;S. Liang;A. Hsueh
通讯作者：
S. Hsu;S. Liang;A. Hsueh
影响因子：
2.6
作者：
Becker, L.;Huang, Q.;Mashimo, H.
通讯作者：
Mashimo, H.