Urban-rural differences in breast cancer incidence in Egypt (1999-2006)
Urban-rural differences in breast cancer incidence in Egypt (1999-2006)
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DOI：
10.1016/j.breast.2010.04.005
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发表时间：
2010-10-01
期刊：
影响因子：
3.9
通讯作者：
Merajver, Sofia D.
中科院分区：
文献类型：
--
作者：
Dey, Subhojit;Soliman, Amr S.;Merajver, Sofia D.
目的：描述埃及Gharbiah地区乳腺癌发病率的城乡差异，并调查这些差异是否可以用已知的乳腺癌危险因素来解释。方法：我们使用埃及Gharbiah基于人群的癌症登记数据来评估从1999年到2006年的乳腺癌发病率。埃及人口普查提供了特定地区的人口、年龄和城乡分类数据。结果：总体上，城市乳腺癌发病率是农村的3~4倍(城市为60.9/10(5)年，农村为17.8/10(5)年；IRR=3.73，95%CI=3.30，4.22)。在所有年龄段中，城市地区的乳腺癌发病率一直较高。在较发达的坦塔和迈哈拉地区，乳腺癌的发病率也较高。结论：城市和较发达人群的乳腺癌发病率较高，可能与较高的异种雌激素以及其他内分泌干扰物和遗传毒性物质的暴露有关。(C)2010爱思唯尔有限公司。保留所有权利。
Objective: To describe urban rural differences in breast cancer incidence in Gharbiah, Egypt and to investigate if these differences could be explained by known risk factors of breast cancer.Methods: We used data from the population-based cancer registry of Gharbiah, Egypt to assess breast cancer incidence from 1999 through 2006. The Egyptian census provided data on district-specific population, age, and urban rural classification. Incidence patterns of breast cancer by district and age-specific urban rural differences were analyzed.Results: Overall, incidence rate of breast cancer was three to four times higher in urban areas than in rural areas (60.9/10(5)-year for urban areas versus 17.8/10(5)-year for rural areas; IRR = 3.73, 95% CI = 3.30, 4.22). Urban areas had consistently higher incidence of breast cancer across all age-groups for all years. Higher incidence of breast cancer was also seen in the more developed districts of Tanta and El-Mehalla.Conclusions: Higher incidence of breast cancer in urban and more developed populations might be related to higher exposure to xenoestrogens, as well as other endocrine disruptors and genotoxic substances. (C) 2010 Elsevier Ltd. All rights reserved.