Preparation of high-purity lactulose through efficient recycling of catalyst sodium aluminate and nanofiltration: a pilot-scale purification
Preparation of high-purity lactulose through efficient recycling of catalyst sodium aluminate and nanofiltration: a pilot-scale purification
复制标题
催化剂铝酸钠高效回收和纳滤制备高纯度乳果糖：中试规模纯化
DOI：
10.1002/jsfa.9076
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发表时间：
2018
影响因子：
4.1
通讯作者：
Yang Ruijin
中科院分区：
文献类型：
--
作者：
Wang Mingming;Admassu Habtamu;Gasmalla Mohammed A. A.;Hua Xiao;Yang Ruijin
BACKGROUNDLactulose, a valuable lactose-originated bifidus factor' product, is exclusively produced by chemical-based isomerization commercially. A complexing agent of sodium aluminate exhibiting high conversion efficiency and strong recyclable stability is more practical for industrial applications. In this study, efficient purification of high-purity lactulose through recycling of sodium aluminate and further desalination by nanofiltration (NF) was implemented on a pilot scale. RESULTSOver 99.5% of the catalyst was prior recycled in the form of Al(OH)(3) precipitate by pH-induced precipitation and centrifugation; residual aluminum was further absorbed by ion exchange resin to an acceptable level (10mgkg(-1)). Subsequently, impurities (monosaccharides and NaCl) were ideally separated from lactulose syrup by NF based on their significant retention differences (lactulose 94.8-97.2% > lactose 86.2-93.5% > monosaccharides 36.3-48.7% > NaCl 9.5-31.1%). High-purity (>95%) lactulose was obtained with >90% yield in both constant and variable volume diafiltration (CVD and VVD) modes when the volume dilution ratio (V-c/V-f) was 4.0 and 2.5 respectively. Both experimental and predicted results showed that the VVD mode was more water-saving in practice. CONCLUSIONThis is the first trial purification of lactulose syrup from chemical isomerization of lactose catalyzed by sodium aluminate, and the applied methodology is a promising industrial-scale purification strategy. (c) 2018 Society of Chemical Industry
