Injury alters intrinsic functional connectivity within the primate spinal cord
Injury alters intrinsic functional connectivity within the primate spinal cord
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DOI：
10.1073/pnas.1424106112
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发表时间：
2015-05-12
影响因子：
11.1
通讯作者：
Gore, John C.
中科院分区：
文献类型：
--
作者：
Chen, Li Min;Mishra, Arabinda;Gore, John C.
最近的相关低频MRI信号的变化之间的子区域的脊髓在休息中在人类，类似于在大脑中发现的，表明这种休息状态的功能连接构成了一个共同的特点，内在的组织整个中枢神经系统。我们报告我们的检测功能连接在休息的麻醉松鼠猴的脊髓内，并表明，这些网络内的连接的强度被改变的伤害的影响。通过量化脊髓灰质内不同角之间的低频MRI信号相关性，我们发现不同的感觉和运动角之间存在不同的功能连接关系，这种模式类似于由伤害性热或触觉刺激引起的激活模式。所有角在一个单一的脊髓节段功能连接，最强的连接发生在同侧背角和腹角之间。每个角都与相邻节段上的同一角紧密相连，但这种连接性沿着脊髓急剧减少。单侧脊髓损伤明显削弱了强度的intrasegment角连接只在损伤侧和病变下方的切片。这些发现表明，静息状态的功能连接可能是一个有用的生物标志物的功能完整性损伤和恢复脊髓。
Recent demonstrations of correlated low-frequency MRI signal variations between subregions of the spinal cord at rest in humans, similar to those found in the brain, suggest that such resting-state functional connectivity constitutes a common feature of the intrinsic organization of the entire central nervous system. We report our detection of functional connectivity within the spinal cords of anesthetized squirrel monkeys at rest and show that the strength of connectivity within these networks is altered by the effects of injuries. By quantifying the low-frequency MRI signal correlations between different horns within spinal cord gray matter, we found distinct functional connectivity relationships between the different sensory and motor horns, a pattern that was similar to activation patterns evoked by nociceptive heat or tactile stimulation of digits. All horns within a single spinal segment were functionally connected, with the strongest connectivity occurring between ipsilateral dorsal and ventral horns. Each horn was strongly connected to the same horn on neighboring segments, but this connectivity reduced drastically along the spinal cord. Unilateral injury to the spinal cord significantly weakened the strength of the intrasegment horn-to-horn connectivity only on the injury side and in slices below the lesion. These findings suggest resting-state functional connectivity may be a useful biomarker of functional integrity in injured and recovering spinal cords.