Prevention of duodenal ulcer relapse by long-term treatment with omeprazole.
Prevention of duodenal ulcer relapse by long-term treatment with omeprazole.
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长期服用奥美拉唑治疗可预防十二指肠溃疡复发。
DOI：
10.3109/00365529409105360
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
H. Festen
中科院分区：
文献类型：
--
作者：
H. Festen
十二指肠溃疡是一种复发风险很高的慢性疾病，如果不及时治疗，每年复发率为 50-80% (1)。但通过抑制胃酸分泌可以有效降低复发率。尽管许多患者可以通过由患者或医生控制的间歇性治疗进行管理，但对于患有严重疾病和有并发症风险的患者来说，持续的维持治疗通常是必要的 (2)。使用单次夜间剂量的 H2 受体拮抗剂进行维持治疗可将每年的复发率从约 75% 降低至 25% (3)。由于奥美拉唑在十二指肠溃疡的急性治疗中比 H2 受体拮抗剂更有效，几乎所有患者都能在 4 周内痊愈 (4)，因此它在十二指肠溃疡的维持治疗中也可能更有效。迄今为止，三项研究报告了奥美拉唑对十二指肠溃疡复发率的影响。丹麦的一项多中心研究涉及 195 名患者，他们接受奥美拉唑治疗，每天一次 10 毫克，或周五、周六和周日每天一次 20 毫克（周末治疗），或安慰剂 (5)。 6 个月后，接受奥美拉唑治疗的患者的缓解率分别为 67% 和 70%，显着高于接受安慰剂的患者（6 个月后为 17%）。意大利一项对 81 名患者进行的多中心研究发现，奥美拉唑，每天一次 10 毫克，以及周末（周五、周六和周日）每天一次 20 毫克，在预防复发方面同样有效。 6 个月后，缓解患者的比例分别为 81% 和 70% (6)。（摘要截断为 250 字）
Duodenal ulcer is a chronic disease with a high risk of relapse--if left untreated, the relapse rate is 50-80% per year (1). However, the relapse rate can be effectively reduced by inhibition of gastric acid secretion. Although many patients can be managed with episodic therapy, controlled either by the patient or doctor, continuous maintenance treatment is often necessary for patients with severe forms of the disease and those at risk of complications (2). Maintenance therapy with single night-time doses of an H2-receptor antagonist reduces relapse rates from approximately 75% to 25% per year (3). As omeprazole is more effective than the H2-receptor antagonists in the acute treatment of duodenal ulcer, healing virtually all patients within 4 weeks (4), it may also be more effective in the maintenance treatment of duodenal ulcer disease. To date, three studies have reported the effect of omeprazole on relapse rates of duodenal ulcer. A Danish multicentre study involved 195 patients, who were treated with omeprazole, either 10 mg once daily, or 20 mg once daily on Friday, Saturday and Sunday (weekend therapy), or with placebo (5). After 6 months, the remission rates were 67% and 70%, respectively, for those patients receiving omeprazole--significantly higher than in those receiving placebo (17% after 6 months). An Italian multicentre study of 81 patients found that omeprazole, both 10 mg once daily, and 20 mg once daily at weekends (Friday, Saturday and Sunday), was equally effective in preventing relapse. The proportions of patients in remission were 81% and 70%, respectively, after 6 months (6).(ABSTRACT TRUNCATED AT 250 WORDS)