Genetics of Chronic Lymphocytic Leukemia.
Genetics of Chronic Lymphocytic Leukemia.
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DOI：
10.1097/ppo.0000000000000538
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发表时间：
2021-07
期刊：
影响因子：
2.2
通讯作者：
F. Bosch;R. Dalla-Favera
中科院分区：
文献类型：
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作者：
F. Bosch;R. Dalla-Favera
在过去的10年中，通过对慢性淋巴细胞白血病基因组及其相关表观基因组和转录组的综合分析，在了解慢性淋巴细胞白血病的发病机制方面取得了相关进展。这些分析也影响了我们对慢性淋巴细胞白血病的起源和演变的理解，包括对化疗的耐药性和对新型靶向治疗的敏感性和耐药性。本章将回顾这一领域的最新进展，重点是疾病的遗传异质性和遗传病变改变的生物学途径。
ABSTRACT During the past 10 years, relevant advances have been made in the understanding of the pathogenesis of chronic lymphocytic leukemia via the integrated analysis of its genome and related epigenome, and transcriptome. These analyses also had an impact on our understanding of the initiation, as well as of the evolution of chronic lymphocytic leukemia, including resistance to chemotherapy and sensitivity and resistance to novel targeted therapies. This chapter will review the current state of the art in this field, with emphasis on the genetic heterogeneity of the disease and the biological pathways that are altered by the genetic lesions.