Investigation of Glutamine and GABA Levels in Patients With Idiopathic Generalized Epilepsy Using MEGAPRESS
Investigation of Glutamine and GABA Levels in Patients With Idiopathic Generalized Epilepsy Using MEGAPRESS
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DOI：
10.1002/jmri.24611
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发表时间：
2015-03-01
影响因子：
4.4
通讯作者：
Richardson, Mark P.
中科院分区：
文献类型：
--
作者：
Chowdhury, Fahmida A.;O'Gorman, Ruth L.;Richardson, Mark P.
目的特发性全身性癫痫包括一组与棘波放电相关的临床综合征，推测与神经传递的改变有关。本研究的目的是探讨IGE患者额叶兴奋性和抑制性神经传递的谷氨酰胺和-氨基丁酸(GABA)水平是否发生改变。材料与方法对13例IGE患者(8名女性)和16名对照组(9名女性)的前额叶背外侧皮质的30毫升体素进行单体素Mega编辑的磁共振成像(MRI)。代谢物浓度用LC模型计算。结果免疫球蛋白E患者血清谷氨酰胺水平显著高于对照组(P=0.02)。IgE患者血清GABA水平也明显升高(P=0.03)。结论IgE患者额叶谷氨酰胺和GABA水平较对照组升高。由于谷氨酰胺被认为是代谢活性谷氨酸的替代品，它可能是兴奋性神经传递的一个标志。J·马根。雷森。成像2015；41：694-699。(C)2014年威利期刊公司。
PurposeIdiopathic generalized epilepsies (IGE) comprise a group of clinical syndromes associated with spike wave discharges, putatively linked to alterations in neurotransmission. The purpose of this study was to investigate whether patients with IGE have altered glutamine and -aminobutyric acid (GABA) levels indicative of altered excitatory and inhibitory neurotransmission in frontal regions.Materials and MethodsSingle-voxel MEGA-edited PRESS magnetic resonance imaging (MRI) spectra were acquired from a 30-mL voxel in the dorsolateral prefrontal cortex in 13 patients with IGE (8 female) and 16 controls (9 female) at 3T. Metabolite concentrations were derived using LCModel. Differences between groups were investigated using an unpaired t-test.ResultsPatients with IGE were found to have significantly higher glutamine than controls (P = 0.02). GABA levels were also elevated in patients with IGE (P = 0.03).ConclusionPatients with IGE have increased frontal glutamine and GABA compared with controls. Since glutamine has been suggested to act as a surrogate for metabolically active glutamate, it may represent a marker for excitatory neurotransmission. J. Magn. Reson. Imaging 2015;41:694-699. (c) 2014 Wiley Periodicals, Inc.