Fetal sex and leptin concentrations in pregnant females
Fetal sex and leptin concentrations in pregnant females
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DOI：
10.5144/0256-4947.2005.124
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发表时间：
2005-03-01
影响因子：
1.6
通讯作者：
Addar, M
中科院分区：
文献类型：
--
作者：
Al Atawi, F;Warsy, A;Addar, M
背景：成年女性瘦素水平明显高于男性。我们研究了胎儿性别对瘦素和其他妊娠激素水平的影响（孕酮、雌二醇、FSH、LH和β hCG）在妊娠的不同阶段。2001年在沙特阿拉伯利雅得的哈立德国王大学医院随访的孕妇血清瘦素水平估计为第一、第二、第三、第四、第四、第五、第五、第六、第六、第七、第八、第九妊娠晚期和分娩后。结果：妊娠3个月时，怀女胎的孕妇瘦素水平均显著高于怀男胎的孕妇，而其他激素水平两组间无差异。分娩后，两组孕妇血清瘦素水平均下降，但分娩女婴的孕妇血清瘦素水平仍高于对照组，但差异无统计学意义。结论：瘦素可能在胚胎发育过程中起性别调节作用。
BACKGROUND: Adult females have significantly more leptin than males. We investigated the effect of fetal sex on levels of leptin and other pregnancy hormones (progesterone, estradiol, FSH, LH and beta hCG) in pregnant females during different stages of pregnancy.PATIENTS AND METHODS: Serum leptin levels in pregnant females followed at King Khaled University Hospital, Riyadh, Saudi Arabia in the year 2001 were estimated at the first, second, and third trimester of pregnancy as well as after delivery. Progesterone, estradiol, FSH, LH and beta hCG levels were also measured.RESULTS: Leptin levels were significantly higher during all three trimesters in the pregnant females carrying female fetuses compared with those with male fetuses, while other hor mones did not differ between the two groups. After delivery, the leptin levels decreased in both groups, and were still higher in the females who delivered baby girls, but the results were not statistically significant.CONCLUSION: These finding suggests that leptin might play a role in sex regulation during embryonic development.