Dynamic 19F-MRI of pulmonary ventilation using sulfur hexafluoride (SF6) gas
Dynamic 19F-MRI of pulmonary ventilation using sulfur hexafluoride (SF6) gas
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DOI：
10.1002/mrm.1082
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发表时间：
2001-04-01
影响因子：
3.3
通讯作者：
Kauczor, HU
中科院分区：
文献类型：
--
作者：
Schreiber, WG;Eberle, B;Kauczor, HU
建立了一种新的吸入六氟化硫（SF6）气体肺内洗入和洗出动力学动态显像方法。采用梯度回波脉冲序列（回波时间0.5 ms，每次图像测量时间9.1 s），在19 F-19 Larmor频率下对猪肺进行测量。在机械通气猪肺中，在SF6气体的洗入和洗出过程中进行动态MRI，开发了一种后处理策略，用于定量测定噪声存在下的洗出时间常数。当采用低潮气量进行通气时，左肺和右肺的平均洗脱常数分别为4.78 +/- 0.48次呼吸和4.33 +/- 0.76次呼吸，当采用高潮气量通气时，左肺和右肺的平均洗脱常数分别为1.73 +/- 0.16次呼吸和1.85 +/- 0.11次呼吸。总之，SF6气体的屏气MRI在大型动物中是可行的。此外，该方法还可以无创地测定SF6的局部洗入和洗出动力学，并讨论了潜在的人体应用。Magn Reson Med 45：605-613，2001。(C)2001 Wiley-Liss，Inc.
A new method for dynamic imaging of pulmonary wash-in and wash-out kinetics of inhaled sulfur hexafluoride (SF,) gas was developed. Measurements at the fluorine-19 Larmor frequency were performed in pigs using a gradient echo pulse sequence with 0.5 ms echo time and a measurement time of 9.1 s per image, Dynamic MRI was performed during wash-in and washout of SF6 gas in mechanically ventilated porcine lungs, A postprocessing strategy was developed for quantitative determination of wash-out time constants in the presence of noise. Mean wash-out constants were 4.78 +/- 0.48 breaths vs, 4.33 +/- 0.76 breaths for left and right lung when ventilation was performed with low tidal volume, and 1.73 +/- 0.16 breaths vs. 1.85 +/- 0.11 breaths with high tidal volume ventilation, In conclusion, breath-hold MRI of SF6 gas is feasible in large animals. Moreover, regional wash-in and wash-out kinetics of SF6 can be determined noninvasively with this new method, Potential human applications are discussed. Magn Reson Med 45: 605-613, 2001. (C) 2001 Wiley-Liss, Inc.