Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity.
Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity.
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DOI：
10.1016/j.cmet.2015.07.021
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发表时间：
2015-09-01
期刊：
影响因子：
29
通讯作者：
Yannai L
中科院分区：
文献类型：
--
作者：
Hall KD;Bemis T;Brychta R;Chen KY;Courville A;Crayner EJ;Goodwin S;Guo J;Howard L;Knuth ND;Miller BV 3rd;Prado CM;Siervo M;Skarulis MC;Walter M;Walter PJ;Yannai L
限制饮食碳水化合物被认为会导致内分泌适应，从而比限制饮食脂肪更能促进体内脂肪的减少。我们有选择地限制碳水化合物与脂肪的饮食6天，在5天的基线饮食之后，19名肥胖者被限制在代谢病房，他们每天锻炼。受试者在两次住院期间按随机顺序接受两种等卡路里饮食。体脂损失计算为每日脂肪摄入量与居住在代谢室时测量的净脂肪氧化之间的差值。碳水化合物限制导致脂肪氧化持续增加，体脂损失53±6g/d，而脂肪限制不改变脂肪氧化，导致脂肪损失89±6g/d，显著大于碳水化合物限制(p=0.002)。数学模型模拟与这些数据一致，但预测身体会采取行动，减少身体脂肪的差异，等卡路里饮食中碳水化合物和脂肪的变化。
Dietary carbohydrate restriction has been purported to cause endocrine adaptations that promote body fat loss more than dietary fat restriction. We selectively restricted dietary carbohydrate versus fat for 6 days following a 5 day baseline diet in 19 adults with obesity confined to a metabolic ward where they exercised daily. Subjects received both isocaloric diets in random order during each of two inpatient stays. Body fat loss was calculated as the difference between daily fat intake and net fat oxidation measured while residing in a metabolic chamber. Whereas carbohydrate restriction led to sustained increases in fat oxidation and loss of 53±6 g/d of body fat, fat oxidation was unchanged by fat restriction leading to 89±6 g/d of fat loss and was significantly greater than carbohydrate restriction (p=0.002). Mathematical model simulations agreed with these data, but predicted that the body acts to minimize body fat differences with isocaloric diets varying in carbohydrate and fat.