THE OLIVOCEREBELLAR PROJECTION IN THE MONKEY - EXPERIMENTAL STUDIES WITH THE METHOD OF RETROGRADE TRACING OF HORSERADISH-PEROXIDASE
THE OLIVOCEREBELLAR PROJECTION IN THE MONKEY - EXPERIMENTAL STUDIES WITH THE METHOD OF RETROGRADE TRACING OF HORSERADISH-PEROXIDASE
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DOI：
10.1002/cne.902010306
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发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
BRODAL, A
中科院分区：
文献类型：
--
作者：
BRODAL, P;BRODAL, A
将辣根过氧化物酶(HRP)注射到猕猴小脑的不同小叶和小叶后，我们对下橄榄中逆行标记细胞的出现进行了定位。只有显示分子层染色的皮质区域才被认为是HRP的摄取部位。为了便于病例之间的比较和研究结果的呈现，我们构建了一张想象中展开的猕猴下橄榄的图表。研究人员试图将这些发现与猫的橄榄小脑投射数据和小脑纵向带状分区的模式进行比较。在猴子和猫的橄榄球小脑投射的组织之间似乎有非常密切的对应关系。投影被精确地组织起来，看起来纯粹是交叉的。在一些小脑皮质区的投射中，可以显示局部的模式。V、VII和VIII小叶的橄榄传入神经来自内侧副橄榄的尾侧1/2，投射到VOOGD‘’S A区，局部分布与猫相似。注射覆盖前叶外侧区(B区)后，在副橄榄背侧部分可见标记细胞。在某些情况下，对前叶和旁正中小叶的中间部进行染色后，对背侧副橄榄嘴部分(C1和C3区)或内侧副橄榄嘴1/2区(C2区)的细胞进行标记。当注射区域覆盖小脑外侧部分时，在主要橄榄核(投射到D1区和D2区)有标记。虽然不完全是决定性的，但这些发现支持这样的观点，即主要橄榄的腹板供给区D2；背板供给区D1。对文献中关于猴橄榄传入神经的相对稀少的数据进行了简要的讨论。在许多方面，这些投射似乎和猫一样。猫和猴在接受红核传入方面可能存在物种差异。
Following injections of horseradish peroxidase (HRP) in various lobes and lobules of the macaque cerebellum, the occurrence of retrogradely labeled cells in the inferior olive was mapped. Only cortical areas showing staining of the molecular layer were considered as sites of uptake of HRP. To facilitate comparisons between cases and presentation of findings, a diagram of the macaque inferior olive as imagined unfolded was constructed. Attempts were made to compare the findings made with data on the olivocerebellar projection in the cat and the pattern of a longitudinal zonal subdivision of the cerebellum. There appears to be a remarkably close correspondence between the organization of the olivocerebellar projection in the monkey and the cat. The projection is precisely organized and appears to be purely crossed. Within the projections to some of the cerebellar cortical zones a topical pattern can be demonstrated. Olivary afferents to vermal lobules V, VII and VIII are derived from the caudal 1/2 of the medial accessory olive, projecting to Voogd''s zone A. The topical pattern resembles that in the cat. After injections covering the lateral zone of the anterior lobe vermis (zone B), labeled cells are seen in the caudal part of the dorsal accessory olive. In some cases staining of the intermediate part of the anterior lobe and of the paramedian lobule is followed by labeling of cells in the rostral part of the dorsal accessory olive (zones C1 and C3) or in the rostral 1/2 of the medial accessory olive (zone C2). When the injected area covers lateral parts of the cerebellum, there is labeling in the principal olive (projecting to zones D1 and D2). Although not entirely decisive, the findings support the view that the ventral lamella of the principal olive supplies zone D2; the dorsal lamella supplies zone D1. The relatively sparse data in the literature on the afferents to the monkey olive are considered briefly. On many points the projections appear to be as in the cat. There is possibly a species difference between cat and monkey as concerns their receipt of afferents from the red nucleus.