A Pivotal Role of Activation of Complement Cascade (CC) in Mobilization of Hematopoietic Stem/Progenitor Cells (HSPC)
A Pivotal Role of Activation of Complement Cascade (CC) in Mobilization of Hematopoietic Stem/Progenitor Cells (HSPC)
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DOI：
10.1007/978-0-387-78952-1_4
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Ratajczak, Janina
中科院分区：
文献类型：
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作者：
Ratajczak, Mariusz Z.;Wysoczynski, Marcin;Ratajczak, Janina
补体级联（CC）和先天免疫作为造血干/祖细胞（HSPC）运输的重要和未被充分认识的调节剂出现。因此，我们报告了（i）在G-CSF诱导的动员过程中，通过经典的免疫球蛋白（IG）依赖性途径，C在骨髓（BM）中被激活，以及（ii）C3裂解片段增加了HSPC对基质衍生因子-1（SDF-I）梯度的反应性。此外，我们最近在免疫缺陷小鼠中的数据支持CC是调节HSPC从骨髓（BM）进入外周血（PB）的主要因素的概念。因此，根据这些发现，HSPC的动员可以设想为需要通过经典Ig依赖性和/或Ig非依赖性途径激活CC的免疫应答的一部分。因此，CC激活的调节可以允许在HSPC动员较差的患者中开发更有效的动员策略。
Complement cascade (CC) and innate immunity emerge as important and underappreciated modulators of trafficking of hematopoietic stem/progenitor cells (HSPC). Accordingly, we reported that (i) C becomes activated in bone marrow (BM) during G-CSF-induced mobilization by the classical immunoglobulin (Ig)-dependent pathway, and that (ii) C3 cleavage fragments increase the responsiveness of HSPC to an stromal derived factor-1 (SDF-I) gradient. Furthermore, our recent data in immunodeficient mice support the concept that the CC is a major factor modulating egress of HSPC from bone marrow (BM) into peripheral blood (PB). Thus, in light of these findings, mobilization of HSPC could be envisioned as part of an immune response that requires CC activation by the classical Ig-dependent and/or Ig-independent pathways. Hence modulation of CC activation could allow for the development of more efficient mobilization strategies in patients who are poor mobilizers of HSPC.