Histological study of the nasal septal cartilage in BALB/c-bm/bm mouse which spontaneously induces malocclusion
Histological study of the nasal septal cartilage in BALB/c-bm/bm mouse which spontaneously induces malocclusion
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BALB/c-bm/bm自发性错牙合小鼠鼻中隔软骨的组织学研究
DOI：
10.1111/j.1601-6343.2011.01538.x
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发表时间：
2012
影响因子：
3.1
通讯作者：
Iida J.
中科院分区：
文献类型：
--
作者：
Takahashi K;Kajii TS;Tsukamoto Y;Saito F;Wada S;Sugawara-Kato Y;Iida J.
高桥康，Kajii T. S., Tsukamoto Y., Saito F., Wada S., Sugawara‐Kato Y., Iida J.鼻中隔软骨在BALB/c‐bm/bmmouse诱导错颌的组织学研究；15: 84 - 91。©2012 John Wiley & Sons A/ s结构摘要目的：BALB/c‐bm/bmmouse具有短肢和短尾的特征，这是由于欠硫酸化的糖胺聚糖所致。BALB/c‐bm/bmmice患者有时会自发出现前横向牙合。BALB/c‐bm/bmmouse显示短鼻和头盖骨。虽然鼻中隔软骨可能与颅面前部结构的生长有关，但颅面前部结构生长缓慢的原因尚未明确。因此，本研究的目的是评估BALB/c‐bm/ bm小鼠鼻中隔软骨在筛骨和蝶骨交界区域的组织学表现。材料与方法：采用野生型BALB/c小鼠和正常闭塞型BALB/c‐bm/ bm小鼠（bm/bm）。用苏木精和伊红染色2、4、8周龄雌性小鼠矢状面切片进行组织学分析。结果-鼻中隔软骨与筛骨交界区（bm/bm）增生区面积明显小于野生型。在鼻中隔软骨与筛骨和蝶骨交界区域，增殖软骨细胞数量明显较少。在鼻中隔软骨和蝶骨交界区未见正常软骨内成骨。结论：研究结果表明，鼻中隔软骨软骨软骨内成骨障碍导致前颅面结构发育迟缓。
Takahashi K., Kajii T. S., Tsukamoto Y., Saito F., Wada S., Sugawara‐Kato Y., Iida J. Histological study of the nasal septal cartilage in BALB/c‐bm/bmmouse which spontaneously induces malocclusionOrthod Craniofac Res2012;15: 84–91. © 2012 John Wiley & Sons A/SStructured AbstractObjectives –The BALB/c‐bm/bmmouse is characterized by short limbs and short tail attributed to undersulfated glycosaminoglycans. Anterior transverse crossbite sometimes spontaneously appears in BALB/c‐bm/bmmice. The BALB/c‐bm/bmmouse shows a short nose and cranium. The reason for hypo‐growth of anterior craniofacial structures has not been clarified, although the nasal septal cartilage might be related to the growth of anterior craniofacial structures. Therefore, the purpose of this study was to evaluate histological findings of the nasal septal cartilage at the border region of the ethmoid and sphenoid bone in BALB/c‐bm/bmmice.Materials and Methods –BALB/c mice (wild type) and BALB/c‐bm/bmmice with normal occlusion (bm/bm) were used. Sagittal sections of female mice aged 2, 4, and 8 weeks were stained with hematoxylin and eosin for histological analysis.Results –At the border region between the nasal septal cartilage and the ethmoid bone inbm/bm, the area of proliferative zone was significantly smaller than that in wild type. At the border regions between the nasal septal cartilage and both the ethmoid and sphenoid bones, the number of proliferative chondrocytes was significantly smaller. Normal endochondral ossification was not observed at the border region between the nasal septal cartilage and the sphenoid bone inbm/bm.Conclusion –The findings suggest that disorder of endochondral ossification in the nasal septal cartilage contributes to the hypo‐growth of anterior craniofacial structures inbm/bm.