Flexible and Transparent Metal Nanowire Microelectrode Arrays and Interconnects for Electrophysiology, Optogenetics, and Optical Mapping
Flexible and Transparent Metal Nanowire Microelectrode Arrays and Interconnects for Electrophysiology, Optogenetics, and Optical Mapping
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DOI：
10.1002/admt.202100225
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发表时间：
2021-06-10
影响因子：
6.8
通讯作者：
Lu, Luyao
中科院分区：
文献类型：
--
作者：
Chen, Zhiyuan;Boyajian, Nicolas;Lu, Luyao
透明微电极是近年来发展起来的一种无串扰多功能光电生物接口技术。迫切需要能够与软组织系统无缝集成的高性能柔性平台。在这里，银纳米线（Ag NWs）为基础的透明微电极阵列（MEA）和互连的设计，以满足这一需求。纳米线网络在550 nm处表现出>90.0%的高光学透明度，以及在5 mm半径下高达100，000次弯曲循环的上级机械稳定性。Ag纳米线微电极在1 kHz下保持3.4-15 Ω cm（2）的低归一化电化学阻抗，并且互连件表现出4.1-25 Ω sq（-1）的优异薄层电阻（R-sh）。体内组织学分析表明，银纳米线结构是生物相容的。对Langendorff灌注的小鼠和大鼠心脏的研究表明，Ag NWs MEA能够在共定位光遗传起搏和光学映射期间高保真实时监测心律。这项概念验证工作表明，溶液处理的，透明的，灵活的银纳米线结构是下一代大面积多功能生物界面的一个有前途的候选者，用于在基础和转化研究中询问复杂的生物系统。
Transparent microelectrodes have recently emerged as a promising approach for crosstalk-free multifunctional electrical and optical biointerfacing. High-performance flexible platforms that allow seamless integration with soft tissue systems for such applications are urgently needed. Here, silver nanowires (Ag NWs)-based transparent microelectrode arrays (MEAs) and interconnects are designed to meet this demand. The nanowire networks exhibit a high optical transparency >90.0% at 550 nm, and superior mechanical stability up to 100,000 bending cycles at 5 mm radius. The Ag NWs microelectrodes preserve low normalized electrochemical impedance of 3.4-15 omega cm(2) at 1 kHz, and the interconnects demonstrate excellent sheet resistance (R-sh) of 4.1-25 omega sq(-1). In vivo histological analysis reveals that the Ag NWs structures are biocompatible. Studies on Langendorff-perfused mouse and rat hearts demonstrate that the Ag NWs MEAs enable high-fidelity real-time monitoring of heart rhythm during co-localized optogenetic pacing and optical mapping. This proof-of-concept work illustrates that the solution-processed, transparent, and flexible Ag NWs structures are a promising candidate for the next-generation of large-area multifunctional biointerfaces for interrogating complex biological systems in basic and translational research.