A neurotrophic pyrimidine compound, MS-818, enhances EGF-induced restoration of gastric epithelial wounds in vitro.
A neurotrophic pyrimidine compound, MS-818, enhances EGF-induced restoration of gastric epithelial wounds in vitro.
复制标题
神经营养性嘧啶化合物 MS-818 可增强 EGF 诱导的胃上皮伤口体外修复。
DOI：
10.1097/00004836-199800001-00017
复制
发表时间：
1998
影响因子：
2.9
通讯作者：
N. Sato
中科院分区：
文献类型：
--
作者：
S. Watanabe;X. E. Wang;M. Hirose;T. Osada;T. Yoshizawa;H. Tanaka;T. Itatsu;M. Nakajima;J. Yamamoto;H. Miwa;A. Miyazaki;A. Awaya;N. Sato
MS-818 is a novel synthetic pyrimidine compound that stimulates nerve regeneration and promotes synthesis of various growth factors and differentiation of astrocytes. Effects of MS-818 on gastric epithelial cells were assessed using a wound repair model with primary cultured gastric epithelial cells from rabbits. A round wound with a constant cell-free area was created and the process of restoration was monitored by measuring wound size every 12 h. Cell proliferation was monitored by sequential staining with BrdU. As previously reported, EGF (10 ng/ml) accelerated wound repair by promoting cell migration and proliferation. Although MS-818 alone had no effects, MS-818 (10-100 microM) enhanced EGF-induced acceleration of gastric epithelial restoration, including cell migration and proliferation. Although the detailed mechanism of action of this agent is still unclear, MS-818 might have favorable effects on in vivo gastric mucosal repair.
DOI：
--
发表时间：
1984
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Lacy,ER;Ito,S
通讯作者：
Ito,S