Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults
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DOI：
10.1093/aje/kwh161
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发表时间：
2004-06-15
影响因子：
5
通讯作者：
Thun, MJ
中科院分区：
文献类型：
--
作者：
Coughlin, SS;Calle, EE;Thun, MJ
几项研究表明，糖尿病可能会改变患多种癌症的风险，这种关联在生物学上是合理的。为了了解更多关于糖尿病和癌症死亡率之间的关系，作者在一个大型的前瞻性美国队列中研究了与选定癌症的相关性，该队列包括467，922名男性和588，321名女性，他们在1982年登记时没有报告癌症史。经过16年的死亡率随访，糖尿病与男性致命性结肠癌显著相关（多变量相对风险（RR）= 1.20，95%置信区间（CI）：1.06，1.37）和女性（RR = 1.24，95%CI：1.07，1.43）和胰腺癌男性（RR = 1.48，95%CI：1.27，1.73）和女性（RR = 1.44，95%CI：1.21，1.72）。对于男性，糖尿病与肝癌（RR = 2.19，95% CI：1.76，2.72）和膀胱癌（RR = 1.43，95% CI：1.14，1.80）显著相关。此外，糖尿病与女性乳腺癌显著相关（RR = 1.27，95%CI：1.11，1.45）。这些关联不能用高体重来解释。我们的研究结果表明，糖尿病是结肠癌、胰腺癌、女性乳腺癌以及男性肝癌和膀胱癌死亡率的独立预测因子。
Several studies have suggested that diabetes mellitus may alter the risk of developing a variety of cancers, and the associations are biologically plausible. To learn more about the relation between diabetes and cancer mortality, the authors examined associations with selected cancers in a large, prospective US cohort of 467,922 men and 588,321 women who had no reported history of cancer at enrollment in 1982. After 16 years of mortality follow-up, diabetes was significantly associated with fatal colon cancer in men (multivariate relative risk (RR) = 1.20, 95% confidence interval (CI): 1.06, 1.37) and women (RR = 1.24, 95% CI: 1.07, 1.43) and with pancreatic cancer in men (RR = 1.48, 95% CI: 1.27, 1.73) and women (RR = 1.44, 95% CI: 1.21, 1.72). For men, diabetes was significantly associated with liver cancer (RR = 2.19, 95% CI: 1.76, 2.72) and bladder cancer (RR = 1.43, 95% CI: 1.14, 1.80). In addition, diabetes was significantly associated with breast cancer in women (RR = 1.27, 95% CI: 1.11, 1.45). These associations were not explained by high body mass. Our findings suggest that diabetes is an independent predictor of mortality from cancer of the colon, pancreas, female breast, and, in men, of the liver and bladder.