A Signal-Passing DNA-Strand-Exchange Mechanism for Active Self-Assembly of DNA Nanostructures.
A Signal-Passing DNA-Strand-Exchange Mechanism for Active Self-Assembly of DNA Nanostructures.
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DOI：
10.1002/anie.201500252
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发表时间：
2015-05-11
期刊：
影响因子：
--
通讯作者：
Seeman NC
中科院分区：
文献类型：
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作者：
Padilla JE;Sha R;Kristiansen M;Chen J;Jonoska N;Seeman NC
DNA 纳米结构瓦片在本文描述的系统中的自身自组装中发挥着积极作用，由此它们启动产生级联组装过程的结合事件。我们提出的 DNA 瓦片具有简单但强大的特性：它们通过在瓦片上传递信号以激活另一端的结合位点来响应瓦片一端的结合事件。此操作允许连续、几乎不可逆的瓷砖自组装，并在自组装过程中实现本地通信。这种局部信号传递机制为 DNA 纳米结构的自主自组装提供了新的控制元素。
DNA nanostructured tiles play an active role in their own self‐assembly in the system described herein whereby they initiate a binding event that produces a cascading assembly process. We present DNA tiles that have a simple but powerful property: they respond to a binding event at one end of the tile by passing a signal across the tile to activate a binding site at the other end. This action allows sequential, virtually irreversible self‐assembly of tiles and enables local communication during the self‐assembly process. This localized signal‐passing mechanism provides a new element of control for autonomous self‐assembly of DNA nanostructures.