Prolactin and psychopathology in schizophrenia: a literature review and reappraisal.
Prolactin and psychopathology in schizophrenia: a literature review and reappraisal.
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DOI：
10.1155/2014/175360
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发表时间：
2014
影响因子：
2.4
通讯作者：
Rajkumar RP
中科院分区：
文献类型：
--
作者：
Rajkumar RP
抗精神病药物可显著增加垂体前叶激素催乳素的分泌，导致精神分裂症患者出现一系列不良反应。然而，各种研究的证据表明，催乳素也可能与这些患者的症状特征和治疗反应有关，最近的工作已经发现，即使在无药物的患者中，催乳素分泌也存在变化。在本文中，选择性审查有关催乳素和精神分裂症，包括挑战和激发研究的所有相关研究。这项工作的影响进行了批判性的讨论。一个尝试性的模型，综合这些研究结果，并认为催乳素在精神分裂症的发展中的重要作用，概述。
Secretion of the anterior pituitary hormone prolactin can be significantly increased by antipsychotic drugs, leading to a range of adverse effects in patients with schizophrenia. However, there is evidence from a variety of studies that prolactin may also be related to symptom profile and treatment response in these patients, and recent work has identified variations in prolactin secretion even in drug-free patients. In this paper, a selective review of all relevant studies pertaining to prolactin and schizophrenia, including challenge and provocation studies, is presented. The implications of this work are discussed critically. A tentative model, which synthesizes these findings and argues for a significant role for prolactin in the development of schizophrenia, is outlined.