Effects of a Rebamipide Mouthwash on Stomatitis Caused by Cancer Chemotherapy Evaluation of the Efficacy by Patients Themselves
Effects of a Rebamipide Mouthwash on Stomatitis Caused by Cancer Chemotherapy Evaluation of the Efficacy by Patients Themselves
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DOI：
10.1248/yakushi.17-00042
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发表时间：
2017-08-01
影响因子：
0.3
通讯作者：
Hanawa, Takehisa
中科院分区：
文献类型：
--
作者：
Ishii, Naoko;Kawano, Yayoi;Hanawa, Takehisa
在接受化疗的癌症病例中，有30%至40%会发生抗癌药物引起的口腔炎。然而，这种情况的药物在日本还没有上市。在获得伦理委员会的批准后，将含有瑞巴派特作为活性成分的漱口水（瑞巴派特漱口水）给予一名住院患者和四名门诊患者，他们因癌症化疗而发生口腔炎。从瑞巴派特漱口水给药后14天开始，患者对口腔状态、疼痛程度和饮食进行口腔炎调查评分，并在口腔炎日记中记录漱口次数以及任何口腔炎观察结果。将三种类型的调查部分中的每一种的得分的总得分分为0至4级，并评价为口腔炎评价得分（SES）。治疗14 d内，5例患者中有3例SES变为“0”。1例患者SES无变化。在其余患者中，SES一度变为“0”，但随后再次升高。使用图像分析软件（ImageJ），测量观察到口腔炎的面积。当比较SES和同意参加的患者的面积变化时，即使在SES没有变化的期间，也观察到口腔炎程度逐渐降低。让病人填写观察表，对掌握门诊病人的症状变化是有效的。
Anticancer drug-induced stomatitis develops in 30% to 40% of cancer cases that undergo chemotherapy. However, medications for this condition are not commercially available in Japan. Upon obtaining approval of the ethics committee, a mouthwash containing rebamipide as the active ingredient (rebamipide mouthwash) was administered to one inpatient and four outpatients, who had developed stomatitis caused by cancer chemotherapy. Starting from 14 d after the administration of the rebamipide mouthwash, the patients scored a stomatitis survey on oral state, pain level, and diet and recorded the number of times they gargled, as well as any stomatitis observations, in a stomatitis diary. The total scores for the points for each of the three types of survey sections were classified into Grades 0 to 4 and evaluated as a stomatitis evaluation score (SES). The SES became "0" in three out of the five patients within 14 d of treatment. No change in SES was found in one patient. In the remaining patients, SES became "0" once but increased again later. Using image analysis software (ImageJ), the area at which the stomatitis was observed was measured. When comparing SES and change in the area in patients who agreed to participate, gradual reductions in the extent of stomatitis was observed even during the period when SES did not change. Having patients fill in an observation chart was effective for grasping changes in symptoms in outpatients.