Emerging approaches of traditional Chinese medicine formulas for the treatment of hyperlipidemia
Emerging approaches of traditional Chinese medicine formulas for the treatment of hyperlipidemia
复制标题
中药方剂治疗高脂血症的新途径
DOI：
10.1016/j.jep.2012.01.027
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发表时间：
2012-03-27
影响因子：
5.4
通讯作者：
Du, Lijun
中科院分区：
文献类型：
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作者：
Xie, Weidong;Zhao, Yunan;Du, Lijun
民族药理学相关性：传统中药（TCM）配方自古以来就在中国被广泛用于治疗某些疾病（例如，痰、湿、瘀。近年来，这些药物的作用越来越多地被证明对高脂血症患者有帮助。本研究的目的：本文旨在描述中医药疗效的科学证据，并试图确定治疗高脂血症的潜在中药配方。材料和方法：中国国家食品药品监督管理局（SFDA）批准的中药配方来源于SFDA官方网站通过互联网（Elsevier，ACS，Wiley Online Library，SpringerLink，PubMed，Web of Science，CNKI，Baidu，Google）和图书馆，对截至2011年10月31日的50多个中药方剂降血脂作用的人体和动物实验证据进行了综述。这些草药主要可以分为三类：（1）促进排泄的草药，通常通过减少食物滞留。增强泻下作用，促进利尿和利胆作用，例如，枸杞子（原文如此）、甘草（原文如此）、决明子（原文如此）、甘草（原文如此）、泽泻（原文如此）和茵陈（原文如此）;（2）作用于心血管系统的草药，通常基于中医理论通过改善血液循环，例如，甘草、荷花、莲藕;（3）具有滋补作用的草药，例如，结论：中药复方治疗高脂血症的基本途径有增强排泄功能、改善心血管系统和强化补益作用三种。这些方法可能有助于控制血脂水平，预防心血管并发症，并调整高血压患者的身体功能。然而，需要这些治疗有效性的确凿证据。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Ethnopharmacological relevance: Traditional Chinese medicine (TCM) formulas have been widely used in China since ancient times to treat certain diseases (e.g., phlegm, dampness and blood stasis). Recently, the effects of these medicines have been increasingly demonstrated to be helpful for hyperlipidemic patients.Aim of the study: This manuscript aims to describe the scientific evidence for the efficacy of TCM and attempts to identify potential TCM formulas for treating hyperlipidemia.Materials and methods: TCM formulas approved by the State Food and Drug Administration of China (SFDA) were sourced from the official SFDA website (http://www.sda.gov.cn/) Human and animal evidence for the hypolipidemic effects of herbs from TCM formulas were reviewed via the Internet (Elsevier, ACS, Wiley Online Library, SpringerLink, PubMed, Web of Science, CNKI, Baidu, and Google) and libraries up to October 31, 2011.Results: More than 50 TCM formulas have been used to treat hyperlipidemia. These herbs can primarily be grouped into three categories: (1) herbs promoting excretions, generally by reducing food retention. enhancing purgative effects, and promoting diuresis and choleretic effects, e.g., Fructus Crataegi (sic), Radix Polygoni Munition ((sic)), Semen Cassiae ((sic)), and Radix et Rhizoma Rhei ((sic)), Rhizoma alismatis ((sic)), and Herba Artemisiae Scopariae ((sic)); (2) herbs acting on the cardiovascular system, generally by improving blood circulation based on TCM theories, e.g., Radix Salviae Miltiorrhizae ((sic)), Radix Puerariae ((sic)), Rhizoma Chuanxiong ((sic)), Flos Carthami ((sic)), and Folium Nelumbinis ((sic)); and (3) herbs that have tonic effects, e.g., Fructus Lycii ((sic)), Radix Ginseng ((sic)), and Radix Astragali ((sic)).Conclusions: Three basic approaches, including excretory function enhancement, cardiovascular system improvement, and tonic effect reinforcement, are emerging among TCM formulas for the treatment of hyperlipidemia. These approaches may be useful in controlling blood lipid levels, preventing cardiovascular complications, and adjusting bodily functions in hyperlipidemic patients. However, solid evidence of the efficacy of these treatments is required. (C) 2012 Elsevier Ireland Ltd. All rights reserved.