From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth.
From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth.
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DOI：
10.1017/s0954579417001419
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发表时间：
2017-12
影响因子：
3.3
通讯作者：
Cicchetti D
中科院分区：
文献类型：
--
作者：
Handley ED;Rogosch FA;Cicchetti D
本研究测试了FKBP 5结合蛋白5（FKBP 5）的遗传变异的作用，在一个内在的途径，从儿童虐待，以新兴的成人问题饮酒的样本中的非洲裔美国青年（N = 280），从11岁到20岁的前瞻性。具体而言，无论是儿童期内化症状和新兴的成人紧张减少酒精预期依次调解儿童虐待对新兴的成人问题饮酒的影响，以及FKBP 5是否缓和这些协会进行了调查。结果表明，具有至少一个拷贝的FKBP 5 CATT单倍型（次要等位基因）的个体比没有这种基因型谱的个体更容易穿越假设的内在风险途径。综上所述，我们的研究结果1）强调了FKBP 5遗传变异在早期逆境中的重要性; 2）支持两种预期的内在途径的顺序机制对问题饮酒的作用，即儿童期内在症状和新兴的成人紧张减轻酒精预期; 3）确定了一个受虐待儿童亚组，该亚组最容易沿着沿着这种不太常见的风险途径发展。
The present study tested the role of FKBP5 binding protein 5 (FKBP5) genetic variation in an internalizing pathway from child maltreatment to emerging adult problem drinking among a sample of African-American youth (N = 280) followed prospectively from ages 11 to 20. Specifically, whether childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies sequentially mediate the effect of child maltreatment on emerging adult problem drinking and whether FKBP5 moderates these associations were investigated. Results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Taken together our findings 1) highlight the importance of FKBP5 genetic variation in the context of early adversity; 2) support the role of two prospective sequential mechanisms of an internalizing pathway to problematic drinking, namely childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies; 3) identify a subgroup of maltreated children most susceptible to progressing along this less common pathway of risk.