CISPLATIN AND DNA-REPAIR IN CANCER-CHEMOTHERAPY
CISPLATIN AND DNA-REPAIR IN CANCER-CHEMOTHERAPY
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DOI：
10.1016/s0968-0004(00)89095-7
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发表时间：
1995-10-01
影响因子：
13.8
通讯作者：
LIPPARD, SJ
中科院分区：
文献类型：
--
作者：
ZAMBLE, DB;LIPPARD, SJ
顺铂是一种DNA损伤剂，是最广泛使用的抗癌药物之一。与这类化疗化合物的所有成员一样，如果肿瘤细胞通过各种机制（包括增强的DNA修复）变得耐药，顺铂的临床成功就会受到影响。除了在耐药性中的作用外，DNA修复还与顺铂的细胞毒性机制有关。被药物损伤的DNA已被证明是探索核苷酸切除修复途径细节的有价值的工具。
Cisplatin, a DNA-damaging agent, is one of the most widely used anticancer drugs. As with all members of this class of chemotherapeutic compounds, the clinical success of cisplatin is compromised if tumor cells become resistant by various mechanisms, including enhanced DNA repair. In addition to its role in resistance, DNA repair has been linked to the cytotoxic mechanism of cisplatin. DNA damaged by the drug has proved to be a valuable tool for exploring the details of the nucleotide excision repair pathway.