Intracerebral haemorrhage associated with hourly concentration of ambient particulate matter: case-crossover analysis
Intracerebral haemorrhage associated with hourly concentration of ambient particulate matter: case-crossover analysis
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DOI：
10.1136/oem.2005.021097
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发表时间：
2007-01-01
影响因子：
4.9
通讯作者：
Fukuhara, S.
中科院分区：
文献类型：
--
作者：
Yamazaki, S.;Nitta, H.;Fukuhara, S.
目的：研究关联的每小时的时间滞后浓度的环境颗粒物和死亡，由于stroke.Methods：死亡率数据为5年（1990年1月至1994年12月），从日本厚生劳动省。只有当死者在死亡时年龄在65岁或以上，如果死亡是由于脑出血或缺血性中风，如果死者住在13个主要城市地区之一时，数据才被使用。每小时平均浓度的PM 7，NO2，和光化学氧化剂在13个地区的监测站进行了测量。时间分层病例交叉分析用于检查触发卒中死亡率的证据的数据。死亡前约2小时测量的PM 7 1小时平均浓度与4月至9月因脑出血死亡的风险相关（比值比= 2.40，95% CI 1.48至3.89，暴露于PM 7超过200 μ g/m（3）（阈值））。较高的风险与PM 7的24小时平均浓度无关。PM 7与缺血性stroke.Conclusions死亡无关：短暂高浓度的PM 7与脑出血死亡有关。颗粒物的空气质量标准或准则不仅应以24小时平均浓度为基础，而且应以每小时数据为基础。
Aims: To examine the association of hourly time lagged concentration of ambient particulate matter and death due to stroke.Methods: Mortality data for five years (January 1990 to December 1994) were obtained from the Ministry of Health, Labour, and Welfare of Japan. Data were used only if the deceased was 65 years old or older at the time of death, if death was attributed to intracerebral haemorrhage or ischaemic stroke, and if the deceased lived in one of 13 major urban areas. Hourly mean concentrations of PM7, NO2, and photochemical oxidants were measured at monitoring stations in the 13 areas. Time stratified case-crossover analysis was used to examine the data for evidence of triggering stroke mortality.Results: The 1-hour mean concentration of PM7 measured about 2 hours before death was associated with the risk of death due to intracerebral haemorrhage from April to September (odds ratio = 2.40, 95% CI 1.48 to 3.89, for exposure to PM7 of more than 200 mu g/m(3) (threshold)). The higher risk was independent of the 24-hour mean concentration of PM7. PM7 was not associated with death due to ischaemic stroke.Conclusions: Transiently high concentrations of PM7 are associated with death due to intracerebral haemorrhage. Air quality standards or guidelines for particulate matter should be based not only on 24-hour mean concentrations, but also on hourly data.