Weight change and prostate cancer incidence and mortality
Weight change and prostate cancer incidence and mortality
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DOI：
10.1002/ijc.27414
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发表时间：
2012-10-01
影响因子：
6.4
通讯作者：
Giles, Graham G.
中科院分区：
文献类型：
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作者：
Bassett, Julie K.;Severi, Gianluca;Giles, Graham G.
肥胖与前列腺癌风险之间的关系已被广泛研究，但结果不一致，特别是肿瘤侵袭性。很少有研究调查体重变化和前列腺癌发病率或死亡率。使用墨尔本协作队列研究，该研究招募了17，045名年龄在40至69岁之间的男性，我们调查了18岁时报告的体重和体重指数（BMI）之间的关系，并在研究开始时测量，身高，18岁和研究开始之间的体重变化以及前列腺癌的发病率和死亡率。使用考克斯回归估计风险比（HR）和95%置信区间（CI）。在对16，514名男性的随访期间（平均= 15年），我们确定了1，374例前列腺癌事件，其中410例被归类为侵袭性，139例死于前列腺癌。所有前列腺癌的发病率与体型或体重变化无关。研究入组时的体重和BMI与侵袭性前列腺癌风险呈正相关（HR = 1.06，95% CI：1.001.13/5 kg; HR = 1.27，95% CI：1.081.49/5 kg/m2）和前列腺癌死亡率（HR = 1.12，95% CI：1.011.23/5 kg; HR = 1.49，95% CI：1.112.00/5 kg/m2）。体重增加与前列腺癌死亡率呈正相关（HR = 1.13，95% CI：每增加5 kg为1.021.26）;与对照组相比，
The relationship between obesity and prostate cancer risk has been studied extensively but with inconsistent findings, particularly for tumor aggressiveness. Few studies have investigated weight change and prostate cancer incidence or mortality. Using the Melbourne Collaborative Cohort Study, which recruited 17,045 men aged between 40 and 69 years at study entry, we investigated associations between reported weight and body mass index (BMI) at age 18 and measured at study entry, height, weight change between age 18 and study entry and prostate cancer incidence and mortality. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression. During follow-up (mean = 15 years) of 16,514 men, we ascertained 1,374 incident prostate cancers of which 410 were classified as aggressive, and 139 deaths from prostate cancer. The incidence of all prostate cancer was not associated with body size or weight change. Weight and BMI at study entry were positively associated with aggressive prostate cancer risk (HR = 1.06, 95% CI: 1.001.13 per 5 kg; HR = 1.27, 95% CI: 1.081.49 per 5 kg/m2) and prostate cancer mortality (HR = 1.12, 95% CI: 1.011.23 per 5 kg; HR = 1.49, 95% CI: 1.112.00 per 5 kg/m2). Weight gain was positively associated with prostate cancer mortality (HR = 1.13, 95% CI: 1.021.26 per 5 kg increment); the HR for =20 kg weight gain between age 18 and study entry compared to