Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression.
Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression.
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DOI：
10.1158/0008-5472.can-08-0955
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发表时间：
2008-07-01
期刊：
影响因子：
11.2
通讯作者：
Tsai MJ
中科院分区：
文献类型：
--
作者：
Yan J;Erdem H;Li R;Cai Y;Ayala G;Ittmann M;Yu-Lee LY;Tsai SY;Tsai MJ
类固醇受体辅活化子-3(SRC-3)/AIB1是p160核受体辅活化子家族的成员，参与细胞的发育和细胞周期进程。我们先前的研究表明SRC-3/AIB1是前列腺癌细胞增殖和存活所必需的。在此，我们报道了SRC-3/AIB1的高表达与前列腺癌的精囊侵袭和淋巴转移密切相关。此外，SRC-3/AIB1与前列腺癌细胞迁移和侵袭增加有关。SRC-3/AIB1是粘着斑翻转和粘着斑激酶激活所必需的。此外，SRC-3/AIB1通过共同激活AP-1和PEA3，直接调控基质金属蛋白酶(MMP2)和MMP13的转录。综上所述，这些数据表明SRC-3/AIB1在前列腺癌细胞的侵袭和转移中起重要作用。
Steroid receptor coactivator-3 (SRC-3)/AIB1 is a member of the p160 nuclear receptor coactivator family involved in development and cell cycle progression. We previously showed that SRC-3/AIB1 is required for prostate cancer cell proliferation and survival. Here, we reported that the elevated SRC-3/AIB1 expression is significantly correlated with human prostate cancer seminal vesicle invasion and lymph node metastasis. Furthermore, SRC-3/AIB1 is associated with increased prostate cancer cell migration and invasion. SRC-3/AIB1 is required for focal adhesion turnover and focal adhesion kinase activation. In addition, SRC-3/AIB1 directly regulates transcription of matrix metalloproteinase (MMP)-2 and MMP-13 through its coactivation of AP-1 and PEA3. Taken together, these data suggest that SRC-3/AIB1 plays an essential role in prostate cancer cell invasion and metastasis.