Functional Imaging of the Implicit Association of the Self With Life and Death
Functional Imaging of the Implicit Association of the Self With Life and Death
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DOI：
10.1111/sltb.12543
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发表时间：
2019-12-01
影响因子：
3.2
通讯作者：
Zarate, Carlos A., Jr.
中科院分区：
文献类型：
--
作者：
Ballard, Elizabeth D.;Reed, Jessica L.;Zarate, Carlos A., Jr.
目的鉴别自杀意念的客观标志是一种迫切的需求。一个潜在的自杀风险标记是自杀内隐联想任务（S-IAT），这是一个行为任务，它使用不同的反应时间来比较自我与死亡之间的内隐联想和自我与生命之间的内隐联想。在S-IAT中，自我与死亡之间的联系越强的个体，未来更有可能尝试自杀。为了更好地理解自我与生或死之间的内隐关联的神经基础，对S-IAT的功能磁共振成像（fMRI）版本进行了改编，并在健康志愿者中进行了试验。方法对28名年龄18-65岁的健康志愿者（14F/14M）进行fMRI版S-IAT。结果：行为结果与非扫描仪版本的任务相当。这项任务与情绪处理相关区域的神经激活模式有关，特别是脑岛和右腹外侧前额叶皮层。S-IAT功能磁共振任务的表现可能反映了在扫描仪外获得的分数。在未来的评估中，这项任务可以帮助评估自杀风险增加的个体在对自我/死亡和自我/生命刺激的反应中是否表现出不同的神经激活模式。
Objective A critical need exists to identify objective markers of suicide ideation. One potential suicide risk marker is the Suicide Implicit Association Task (S-IAT), a behavioral task that uses differential reaction times to compare the implicit association between the self and death to the implicit association between the self and life. Individuals with a stronger association between the self and death on the S-IAT are more likely to attempt suicide in the future. To better understand the neural underpinnings of the implicit association between self and either life or death, a functional magnetic resonance imaging (fMRI) version of the S-IAT was adapted and piloted in healthy volunteers.Method An fMRI version of the S-IAT was administered to 28 healthy volunteers (ages 18-65, 14F/14M).Results Behavioral results were comparable to those seen in non-scanner versions of the task. The task was associated with patterns of neural activation in areas relevant to emotional processing, specifically the insula and right ventrolateral prefrontal cortex.Conclusions Performance on the S-IAT fMRI task may reflect scores obtained outside of the scanner. In future evaluations, this task could help assess whether individuals at increased risk of suicide display a different pattern of neural activation in response to self/death and self/life stimuli.