Obesity is a risk factor for epidural lipomatosis: a meta-analysis
Obesity is a risk factor for epidural lipomatosis: a meta-analysis
复制标题
肥胖是硬膜外脂肪增多症的危险因素：一项荟萃分析
DOI：
10.1177/23094990211027391
复制
发表时间：
2021-05-01
影响因子：
1.6
通讯作者：
Saad, Muhammad
中科院分区：
文献类型：
--
作者：
Zhang, Bi;Yuan, Haifeng;Saad, Muhammad
目的：这项荟萃分析的目的是总结肥胖因素与脊髓硬膜外脂肪增多症（SEL）之间的关联证据，并评估这些关联的强度和有效性。研究方法：检索Wiley Online Library、PubMed、Embase、科克伦图书馆等电子数据库，手工检索参考文献，时限为数据库建立至2020年5月。采用科克伦指南推荐的偏倚风险评估工具对纳入研究的方法学质量进行评估。采用RevMan 5.3软件进行Meta分析。结果：最终纳入7项研究进行荟萃分析，均为观察性研究，存在混合偏倚风险。这些研究涉及807名患者，平均年龄为64至73.6岁，59.4%的参与者为男性。纳入研究的样本量范围为28 - 288。荟萃分析结果显示，高体重指数（BMI）是影响SEL的因素之一（P < 0.01，MD 1.37，95%CI [0.81，1.92]）。所有综述均存在较高的偏倚风险，最常见的偏倚来源是研究之间没有严格统一的病例诊断标准，部分研究（4项）未明确描述其控制的混杂因素。结论：我们建议医生应将高BMI视为导致SEL的一个因素，并应将积极控制体重作为手术干预前的首选治疗策略。
Purpose: The purpose of this meta-analysis was to summarize the evidence of associations between obesity factors and spinal epidural lipomatosis (SEL) and to evaluate the strength and validity of these associations. Methods: Electronic databases such as Wiley Online Library, PubMed, Embase, Cochrane Library were searched and manual retrieval of references, the time limit was from the establishment of the database to May 2020. Methodological quality evaluations of the included studies were assessed using the bias risk assessment tool recommended by the Cochrane Guidelines. The RevMan 5.3 software was used for meta-analysis. Results: Finally, seven studies were included for meta-analysis, all of which were observational studies with mixed bias risk. These studies involved 807 patients, with an average age of 64 to 73.6 years, and 59.4 percent of the participants were male. The sample sizes for the included studies ranged from 28 to 288. The results of meta-analysis showed that high body mass index (BMI) was one of the factors affecting SEL (P < 0.01, MD 1.37, 95% CI [0.81, 1.92]). All reviews had a high risk of bias, and the most common source of bias was that there was no strict unified case diagnosis standard between researches, and some studies (four items) did not clearly describe the confounders that they controlled. Conclusions: We suggest that physicians should consider high BMI as a factor leading to SEL, and to control body weight actively should be considered as the preferred treatment strategy before surgical intervention is conducted.