Alanine aminotransferase, HCV RNA levels and pro-inflammatory and pro-fibrogenic cytokines/chemokines during acute hepatitis C virus infection
Alanine aminotransferase, HCV RNA levels and pro-inflammatory and pro-fibrogenic cytokines/chemokines during acute hepatitis C virus infection
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DOI：
10.1186/s12985-016-0482-x
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发表时间：
2016-02-24
期刊：
影响因子：
4.8
通讯作者：
Applegate, Tanya L.
中科院分区：
文献类型：
--
作者：
Hajarizadeh, Behzad;Lamoury, Francois M. J.;Applegate, Tanya L.
背景资料：本研究评估了丙氨酸氨基转移酶（ALT）和丙型肝炎病毒（HCV）的RNA水平与促炎性和促纤维化细胞因子和趋化因子在急性HCV infection.Methods的潜在的HCV immunopathogenesization.Methods：参与者在ATAHC研究，一项前瞻性研究，最近的HCV感染，与HCV RNA检测的时候，HCV检测。检测27种细胞因子和趋化因子的血浆水平，并评估其与ALT和HCV RNA水平的相关性。结果：117例患者血浆中干扰素-γ诱导蛋白-10（IP-10）和巨噬细胞炎性蛋白-1 β（MIP-1 β）水平与正常对照组比较，差异有统计学意义（P < 0. 05）。MIP-1 β与ALT水平呈正相关（IP-10：r = 0.42，P < 0.001; MIP-1 β：r = 0.29，P = 0.001）和HCV RNA水平（IP-10：rs = 0.44，P < 0.001; MIP-1 β：rs = 0.43，P < 0.001）。使用线性回归，在调整性别、年龄、感染持续时间、有症状感染、HIV合并感染、干扰素-λ rs 12979860基因型、HCV基因型和检测运行后，ALT水平较高（β = 0.20; 95% CI：0.07，0.32; P = 0.002）和HCV RNA水平> 400，000 IU/mL（vs. 400，000 IU/mL（vs.
Background: This study assessed the association of alanine-aminotransferase (ALT) and hepatitis C virus (HCV) RNA levels with pro-inflammatory and pro-fibrogenic cytokines and chemokines during acute HCV infection to provide further insight into the potential HCV immunopathogenesis.Methods: Participants in the ATAHC study, a prospective study of recent HCV infection, with detectable HCV RNA at the time of HCV detection were included. Plasma levels of 27 cytokines and chemokines were measured and their correlation with ALT and HCV RNA levels were assessed. Log(10) transformed cytokines and ALT values were used in the analysis.Results: Among 117 individuals, the plasma levels of interferon-gamma inducible protein-10 (IP-10) and macrophage inflammatory protein-1beta (MIP-1 beta) were positively correlated with ALT levels (IP-10: r = 0.42, P < 0.001; MIP-1 beta: r = 0.29, P = 0.001) and HCV RNA levels (IP-10: rs = 0.44, P < 0.001; MIP-1 beta: rs = 0.43, P < 0.001). Using linear regression, after adjusting for sex, age, infection duration, symptomatic infection, HIV co-infection, interferon-lambda rs12979860 genotype, HCV genotype, and assay run, higher ALT levels (beta = 0.20; 95 % CI: 0.07, 0.32; P = 0.002) and HCV RNA levels >400,000 IU/mL (vs. 400,000 IU/mL (vs.