What are the factors affecting the recovery rate of bronchoalveolar lavage fluid?
What are the factors affecting the recovery rate of bronchoalveolar lavage fluid?
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DOI：
10.1111/crj.13462
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发表时间：
2022-03
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影响因子：
--
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支气管肺泡灌洗（BAL）是评估间质性肺疾病的有用检查。较高的BAL液（BALF）回收率是理想的，因为较低的回收率会导致诊断不准确和不良事件增加。很少有研究探讨BALF恢复率是否受临床因素的影响。本研究旨在确定影响BALF恢复率的临床参数及其影响程度。对2013年至2019年期间在千叶大学医院接受BAL的患者数据进行了回顾性分析。使用三等份50 ml生理盐水进行BAL。分析了BALF恢复率与年龄、性别、吸烟状况、基础疾病、手术所用支气管和肺功能等临床参数的潜在相关性。826例患者接受了BAL。平均回收率为52.4%。影响BALF回收率的因素包括男性（比值比[OR]：0.32，95%置信区间[CI]：0.20-0.53，p < 0.001）;年龄≥ 65岁（OR：0.50，95% CI：0.33-0.76，p < 0.001）;使用左支气管（OR：0.46，95% CI：0.30-0.71，p = 0.001）和除中叶支气管或小舌以外的支气管（OR：0.41，95%CI：0.25-0.65，p < 0.001）; 1 s用力呼气量除以用力肺活量<80%（OR：0.42，95%CI：0.40-1.00，p < 0.001）。性别、年龄、用于手术的支气管和肺功能可作为BALF恢复率的术前预测因素。
Bronchoalveolar lavage (BAL) is a useful examination for the evaluation of interstitial lung disease. A high BAL fluid (BALF) recovery rate is desirable because low recovery rates lead to inaccurate diagnoses and increased adverse events. Few studies have explored whether BALF recovery rates are influenced by clinical factors. This study aimed to identify the clinical parameters affecting the recovery rates of BALF and the extent of their effects. Data from patients who underwent BAL at the Chiba University Hospital between 2013 and 2019 were retrospectively reviewed. BAL was performed with three aliquots of 50‐ml physiological saline. The potential association of the BALF recovery rate with clinical parameters such as age, sex, smoking status, underlying disease, bronchus used for the procedure and pulmonary function, was analysed. Eight hundred twenty‐six patients had undergone BAL. The average recovery rate was 52.4%. Factors affecting BALF recovery rates included male sex (odds ratio [OR]: 0.32, 95% confidence interval [CI]: 0.20–0.53, p < 0.001); age ≥ 65 years (OR: 0.50, 95% CI: 0.33–0.76, p < 0.001); use of the left bronchus (OR: 0.46, 95% CI: 0.30–0.71, p = 0.001) and bronchi other than the middle lobe bronchus or lingula (OR: 0.41, 95% CI: 0.25–0.65, p < 0.001); and forced expiratory volume in 1 s divided by forced vital capacity <80% (OR: 0.42, 95% CI: 0.40–1.00, p < 0.001). Sex, age, bronchus used for the procedure and pulmonary function may be useful as pre‐procedural predictors of BALF recovery rates.
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