Pulse steroid therapy for children's severe alopecia areata?
Pulse steroid therapy for children's severe alopecia areata?
复制标题
类固醇冲击治疗儿童严重斑秃？
DOI：
10.1159/000246159
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发表时间：
1997
期刊：
影响因子：
3.4
通讯作者：
Micheline Song
中科院分区：
文献类型：
--
作者：
N. Kiesch;J. Stene;J. Goens;O. Vanhooteghem;Micheline Song
本文报告7例严重、进展迅速的斑秃患儿，采用激素冲击疗法（PST）治疗。AA已存在3-44周，并涉及超过30%的头皮。1例患者出现全秃。静脉注射甲泼尼龙（5 mg/kg，每日两次），持续3天。未发现严重副作用。在12个月随访时，5例患者（71%）发生完全再生。全秃患者无再生。PST似乎是一个有前途的和安全的治疗广泛的，最近发生的AA儿童。在全秃或长期AA中预期无反应。
Seven children with severe, rapidly evolving alopecia areata (AA) were treated with pulse steroid therapy (PST). AA had been present for 3-44 weeks and involved more than 30% of the scalp. One patient had alopecia totalis. Intravenous methylprednisolone (5 mg/kg twice a day) was administered for 3 days. No serious side effects were noted. At the 12-month follow-up, complete regrowth had occurred in 5 patients (71%). The patient with alopecia totalis had no regrowth. PST appears to be a promising and safe treatment for extensive, recent-onset AA in children. No response is to be expected in alopecia totalis or long-standing AA.