Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents
Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents
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DOI：
10.1016/j.atherosclerosis.2010.06.046
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发表时间：
2010-10-01
期刊：
影响因子：
5.3
通讯作者：
Friberg, Peter
中科院分区：
文献类型：
--
作者：
Dangardt, Frida;Osika, Walter;Friberg, Peter
目标：与正常体重的青少年相比，肥胖青少年具有较低的血清omega-3（n-3）多不饱和脂肪酸（PUFA）浓度，增强的炎症活动和内皮功能障碍。我们想评估补充n-3是否会增加肥胖青少年的血清n-3 PUFA浓度，改善血管功能和形态，并降低炎症。方法：25名肥胖青少年（14名女性，11名男性，年龄15.7 ± 1.0岁，BMI 33.8 +/- 3.9）随机接受含1.2 g/天n-3或安慰剂的胶囊3个月。本研究采用双盲、交叉设计进行，洗脱期为6周。在每个治疗期之前和之后获得人体测量、血压测量和空腹血液样本。结果：血清n-3 PUFA浓度随n-3治疗时间延长而升高，但随着n-3治疗时间的延长而升高。与安慰剂相比，n-3治疗的反应性充血反应改善（p < 0.01）。N-3补充还降低了淋巴细胞、单核细胞、TNF-α、IL-6和IL-1 β水平。两个治疗组之间的总胆固醇，三酰甘油，高密度脂蛋白胆固醇，人体测量，血压，脉搏波速度或血管结构无差异，结论：每日补充n-3胶囊增加血清n-3多不饱和脂肪酸浓度，改善血管功能，降低肥胖青少年的炎症程度。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Objective: Compared to normal weight adolescents, obese adolescents have lower serum omega-3 (n-3) polyunsaturated fatty acid (PUFA) concentrations, augmented inflammatory activity and endothelial dysfunction. We wanted to assess whether n-3 supplementation increases the serum n-3 PUFA concentration, improves vascular function and morphology, and lowers inflammation in obese adolescents.Methods: Twenty-five obese adolescents (14 females, 11 males, age 15.7 +/- 1.0 years, BMI 33.8 +/- 3.9) were randomized to receive capsules containing either 1.2 g/day n-3 or placebo for 3 months. The study was performed using a double-blind, cross-over design with a 6-week washout period. Anthropometry, blood pressure measurements and fasting blood samples were obtained before and after each treatment period. The vascular structure and function was measured after each treatment period.Results: The serum n-3 PUFA concentration increased with n-3 treatment. The reactive hyperemia response improved with n-3 treatment compared to placebo (p < 0.01). N-3 supplementation also decreased the lymphocyte, monocyte, TNF-alpha, IL-6 and IL-1 beta levels. No difference was found in the total cholesterol, triacylglycerol, HDL cholesterol, anthropometry, blood pressure, pulse wave velocity or vascular structure between the two treatment groups.Conclusion: Daily supplementation with n-3 capsules increases the serum n-3 PUFA concentration, improves vascular function, and lowers the degree of inflammation in obese adolescents. (C) 2010 Elsevier Ireland Ltd. All rights reserved.