A phase II, randomized trial of neo-adjuvant chemotherapy comparing a three-drug combination of paclitaxel, ifosfamide, and cisplatin (TIP) versus paclitaxel and cisplatin (TP) followed by radical surgery in patients with locally advanced squamous cell cervical carcinoma: the Snap-02 Italian Collaborative Study
A phase II, randomized trial of neo-adjuvant chemotherapy comparing a three-drug combination of paclitaxel, ifosfamide, and cisplatin (TIP) versus paclitaxel and cisplatin (TP) followed by radical surgery in patients with locally advanced squamous cell cervical carcinoma: the Snap-02 Italian Collaborative Study
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DOI：
10.1093/annonc/mdn690
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发表时间：
2009-04-01
影响因子：
50.5
通讯作者：
Rulli, E.
中科院分区：
文献类型：
--
作者：
Lissoni, A. A.;Colombo, N.;Rulli, E.
背景资料：紫杉醇和顺铂（TP）方案新辅助治疗局部晚期宫颈鳞状细胞癌的疗效和耐受性尚不清楚。TIP方案（TP+异环磷酰胺）疗效高，但毒性大，可作为内部对照。患者和方法：共154例患者随机分为TP组（紫杉醇175 mg/m2+顺铂75 mg/m2; n = 80）和TIP组（TP +异环磷酰胺5 g/m2; n = 74），共3个周期，随后行根治性手术。对化疗的病理学反应被分类为最佳[无残留肿瘤（完全反应）或残留疾病，
Background: The efficacy and tolerability of the regimen containing paclitaxel and cisplatin (TP) in the neo-adjuvant treatment of locally advanced squamous cell cervical cancer are unknown. The TIP regimen (TP plus ifosfamide) showed high efficacy but high toxicity and it is used as an internal control.Patients and methods: In all, 154 patients were randomized to TP (paclitaxel 175 mg/m(2) + cisplatin 75 mg/m(2); n = 80) or TIP (TP + ifosfamide 5 g/m(2); n = 74), three cycles, followed by radical surgery. Pathological response to chemotherapy was classified as optimal [no residual tumor (complete response) or residual disease with