Desmoplastic malignant melanoma.
Desmoplastic malignant melanoma.
复制标题
促纤维增生性恶性黑色素瘤。
DOI：
10.1001/archderm.1975.01630180081011
复制
发表时间：
1975
影响因子：
--
通讯作者：
M. Brownstein
中科院分区：
文献类型：
--
作者：
G. R. Frolow;L. Shapiro;M. Brownstein
一名 68 岁男子因手臂肿瘤寻求皮肤科治疗。活检标本显示皮肤中异常、本质上无黑色素、梭形细胞、大量纤维化基质和局灶性表皮浸润。诊断出促纤维增生性恶性黑色素瘤。病灶被广泛切除并进行腋窝淋巴结切除术； 1个淋巴结显示转移。九个月后，他死于广泛的转移性疾病。据我们所知，这是该实体自 1971 年确定以来的第一份报告，也是唯一一个通过初次活检确诊并随后进行明确治疗的病例。促纤维增生性黑色素瘤已与良性纤维化、侵袭性纤维瘤病和纤维肉瘤相混淆，另一个例子是与硬斑病样基底细胞癌和乳腺癌的硬皮样转移性病变，其中促纤维增生性基质可能掩盖皮肤肿瘤的上皮性质。
A 68-year-old man sought dermatologic attention for a tumor of the arm. Biopsy specimen showed abnormal, essentially amelanotic, spindle-shaped cells in the cutis, greatly fibrotic stroma, and focal epidermal invasion. Desmoplastic malignant melanoma was diagnosed. The lesion was widely excised and axillary lymphadenectomy performed; one node showed metastasis. Nine months later, he died with widespread metastatic disease. To our knowledge, this is the first report of this entity since its delineation in 1971 and the only case in which diagnosis was established on initial biopsy and followed by definitive therapy. Desmoplastic melanoma has been confused with benign fibrosis, invasive fibromatosis, and fibrosarcoma, and is another example, with morpheaform basal cell carcinoma and sclerodermoid metastatic lesions from breast carcinoma, in which desmoplastic stroma may obscure the epithelial nature of cutaneous neoplasm.